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  2. Transmissible spongiform encephalopathy - Wikipedia

    en.wikipedia.org/wiki/Transmissible_spongiform...

    For example, Creutzfeldt–Jakob disease has been transmitted to patients taking injections of growth hormone harvested from human pituitary glands, from cadaver dura allografts and from instruments used for brain surgery (Brown, 2000) (prions can survive the "autoclave" sterilization process used for most surgical instruments).

  3. Prion - Wikipedia

    en.wikipedia.org/wiki/Prion

    A prion / ˈ p r iː ɒ n / ⓘ is a misfolded protein that induces misfolding in normal variants of the same protein, leading to cellular death.Prions are responsible for prion diseases, known as transmissible spongiform encephalopathy (TSEs), which are fatal and transmissible neurodegenerative diseases affecting both humans and animals.

  4. Creutzfeldt–Jakob disease - Wikipedia

    en.wikipedia.org/wiki/Creutzfeldt–Jakob_disease

    Astemizole, a medication approved for human use, has been found to have anti-prion activity and may lead to a treatment for Creutzfeldt–Jakob disease. [101] A monoclonal antibody (code name PRN100) targeting the prion protein (PrP) was given to six people with Creutzfeldt–Jakob disease in an early-stage clinical trial conducted from 2018 to ...

  5. Proteinopathy - Wikipedia

    en.wikipedia.org/wiki/Proteinopathy

    [30] [31] In this way, the disease state can be brought about in a susceptible host by the introduction of diseased tissue extract from an affected donor. The best known forms of inducible proteopathy are prion diseases, [32] which can be transmitted by exposure of a host organism to purified prion protein in a disease-causing conformation. [33 ...

  6. List of infections of the central nervous system - Wikipedia

    en.wikipedia.org/wiki/List_of_infections_of_the...

    They include mostly viral infections, less commonly bacterial infections, fungal infections, prion diseases and protozoan infections. Neonatal meningitis is a particular classification by age. By anatomical site

  7. Alarming case of deadly brain disease linked to Covid-19 - AOL

    www.aol.com/news/alarming-case-deadly-brain...

    The most common type in humans is called Creutzfeldt-Jakob disease. Prion diseases occur after a normal prion protein, which is found on the surface of cells, becomes abnormal. ... Treatment is ...

  8. Gerstmann–Sträussler–Scheinker syndrome - Wikipedia

    en.wikipedia.org/wiki/Gerstmann–Sträussler...

    Prion diseases, also called transmissible spongiform encephalopathies (TSEs), are neurodegenerative diseases of the brain thought to be caused by a protein that converts to an abnormal form called a prion. [16] [17] GSS is a very rare TSE, making its genetic origin nearly impossible to determine.

  9. Antiprion drug - Wikipedia

    en.wikipedia.org/wiki/Antiprion_drug

    Antiprion drugs are drugs that work against prions. The discovery of antiprion drugs is a priority because prion diseases are untreatable and fatal. [1] Therefore, it is a therapeutic priority to find effective anti-prion drugs. [citation needed]