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The area under the effect curve (AUEC) is an integral of the effect of a drug over time, estimated as a previously-established function of concentration. It was proposed to be used instead of AUC in animal-to-human dose translation, as computer simulation shows that it could cope better with half-life and dosing schedule variations than AUC.
The main criticism to the ROC curve described in these studies regards the incorporation of areas with low sensitivity and low specificity (both lower than 0.5) for the calculation of the total area under the curve (AUC)., [19] as described in the plot on the right.
Simpson's rules are a set of rules used in ship stability and naval architecture, to calculate the areas and volumes of irregular figures. [1] This is an application of Simpson's rule for finding the values of an integral, here interpreted as the area under a curve.
This can also be seen from the geometric picture: the trapezoids include all of the area under the curve and extend over it. Similarly, a concave-down function yields an underestimate because area is unaccounted for under the curve, but none is counted above. If the interval of the integral being approximated includes an inflection point, the ...
This method was further developed and employed by Archimedes in the 3rd century BC and used to calculate the area of a circle, the surface area and volume of a sphere, area of an ellipse, the area under a parabola, the volume of a segment of a paraboloid of revolution, the volume of a segment of a hyperboloid of revolution, and the area of a ...
Approximating the area under the curve y = x 2 over [0, 2] using the right Riemann sum. Notice that because the function is monotonically increasing, the right Riemann sum will always overestimate the area contributed by each term in the sum (and do so maximally).
Finding the area under a straight-line segment of log–log plot [ edit ] To calculate the area under a continuous, straight-line segment of a log–log plot (or estimating an area of an almost-straight line), take the function defined previously F ( x ) = c o n s t a n t ⋅ x m . {\displaystyle F(x)=\mathrm {constant} \cdot x^{m}.} and ...
One can often quickly calculate this using the PV diagram as it is simply the area enclosed by the cycle. [citation needed] Note that in some cases specific volume will be plotted on the x-axis instead of volume, in which case the area under the curve represents work per unit mass of the working fluid (i.e. J/kg). [citation needed]