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Histidine ball and stick model spinning. Histidine (symbol His or H) [2] is an essential amino acid that is used in the biosynthesis of proteins.It contains an α-amino group (which is in the protonated –NH 3 + form under biological conditions), a carboxylic acid group (which is in the deprotonated –COO − form under biological conditions), and an imidazole side chain (which is partially ...
A polyhistidine-tag, best known by the trademarked name His-tag, is an amino acid motif in proteins that typically consists of at least six histidine (His) residues, often at the N- or C-terminus of the protein. It is also known as a hexa histidine-tag, 6xHis-tag, or His6 tag.
Histidine triad nucleotide-binding protein 1 also known as adenosine 5'-monophosphoramidase is an enzyme that in humans is encoded by the HINT1 gene. [5] [6] HINT1 hydrolyzes purine nucleotide phosphoramidates with a single phosphate group. [7] In addition, functions as scaffolding protein that modulates transcriptional activation. [8]
The enzyme histidine decarboxylase (EC 4.1.1.22, HDC) is transcribed on chromosome 15, region q21.1-21.2, and catalyzes the decarboxylation of histidine to form histamine. In mammals, histamine is an important biogenic amine with regulatory roles in neurotransmission , gastric acid secretion and immune response .
The triad is exemplified by chymotrypsin, [c] a model serine protease from the PA superfamily which uses its triad to hydrolyse protein backbones. The aspartate is hydrogen bonded to the histidine, increasing the pK a of its imidazole nitrogen from 7 to around 12. Histidine is thus able to act as a powerful general base, activating the serine ...
3273 94175 Ensembl ENSG00000113905 ENSMUSG00000022877 UniProt P04196 Q9ESB3 RefSeq (mRNA) NM_000412 NM_053176 RefSeq (protein) NP_000403 NP_444406 Location (UCSC) Chr 3: 186.66 – 186.68 Mb Chr 16: 22.77 – 22.78 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Histidine-rich glycoprotein (HRG) is a glycoprotein that in humans is encoded by the HRG gene. The HRG protein is produced ...
This gene, a member of the histidine triad gene family, encodes a diadenosine P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen -induced damage can lead to translocations and aberrant transcripts of this gene.
However, some people can have elevated levels of p16 but test negative for HPV and vice versa. This is known as discordant cancer. The 5-year survival for people who test positive for HPV and p16 is 81%, for discordant cancer it is 53–55%, and 40% for those who test negative for p16 and HPV. [33] [34]