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Family history of breast cancer. The genetic risk can be passed down through the mother’s or father’s side. Radiation therapy to the chest before the age of 30. Presence of high-risk breast lesions like lobular carcinoma in situ (LCIS), atypical ductal hyperplasia (ADH) and atypical lobular hyperplasia (ALH). [7]
Atypical ductal hyperplasia (ADH) is the term used for a benign lesion of the breast that indicates an increased risk of breast cancer. [1]The name of the entity is descriptive of the lesion; ADH is characterized by cellular proliferation (hyperplasia) within one or two breast ducts and (histomorphologic) architectural abnormalities, i.e. the cells are arranged in an abnormal or atypical way ...
Atypical hyperplasia is a high-risk premalignant lesion of the breast. It is believed that atypical ductal hyperplasia (ADH) is a direct precursor for low-grade mammary ductal carcinoma , whereas atypical lobular hyperplasia (ALH) serves as a risk indicator.
Like the cells of atypical lobular hyperplasia and invasive lobular carcinoma, the abnormal cells of LCIS consist of small cells with oval or round nuclei and small nucleoli detached from each other. [12] Mucin-containing signet-ring cells are commonly seen. LCIS generally leaves the underlying architecture intact and recognisable as lobules.
Stereotactic biopsy is done with the help of a specialized device, which provides mammographic guidance. For a stereotactic biopsy, morbid obesity is a relative contraindication due to weight limitations of the devices. Pregnancy and breast compression size may also be contraindications depending on the modality being used. [15]
Benign proliferative breast disease is a group of noncancerous conditions that may increase the risk of developing breast cancer. Examples include atypical ductal hyperplasia , atypical lobular hyperplasia , and intraductal papillomas .
The American College of Obstetricians and Gynecologists (ACOG) also says that hormonal changes the week before a period can cause breast pain and tenderness. Birth control or hormone therapy.
This genetic mutation is a high-risk factor for the development of breast cancer, family history, or atypical lobular hyperplasia (when irregular cells line the milk lobes.) This type of procedure is said to reduce the risk of breast cancer by 100%. However, other circumstances may affect the outcome.