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The word liposome derives from two Greek words: lipo ("fat") and soma ("body"); it is so named because its composition is primarily of phospholipid.. Liposomes were first described by British hematologist Alec Douglas Bangham [10] [11] [12] in 1961 at the Babraham Institute, in Cambridge—findings that were published 1964.
A ligand-targeted liposome (LTL) is a nanocarrier with specific ligands attached to its surface to enhance localization for targeted drug delivery. The targeting ability of LTLs enhances cellular localization and uptake of these liposomes for therapeutic or diagnostic purposes.
The Journal of Liposome Research is a peer-reviewed academic journal that publishes original research on the topics of liposomes and related systems, lipid-based delivery systems, lipid biology, and both synthetic and physical lipid chemistry.
The use of cationic lipids helps to enhance the overall stability and efficiency of liposomes. Although cationic lipids themselves are able to encapsulate nucleic acids into liposomes, the transfection efficiency is low due to a process known as endosomal escape.
A liposome extruder is a device that prepares cell membranes, exosomes and also generates nanoscale liposome formulations. [ 1 ] [ 2 ] The liposome extruder employs the track-etched membrane to filter huge particles and achieve sterile filtration.
There is an interest in liposomal medicine because it features targeted drug delivery while mitigating the damage to healthy cells and tissues. [15] One of the combination products under liposome therapy that is being researched for cancer therapy applications is immunoliposome therapy. [15]
In biomedical research, unilamellar liposomes are extremely useful to study biological systems and mimicking cell functions. [ 1 ] [ 10 ] As a living cell is very complicated to study, unilamellar liposomes provide a simple tool to study membrane interaction events such as membrane fusion , protein localization in the plasma membrane, study ion ...
(Note- the term “liposome” is in essence synonymous with “vesicle” except that vesicle is a general term for the structure whereas liposome refers to only artificial not natural vesicles) The basic idea of liposomal drug delivery is that the drug is encapsulated in solution inside the liposome then injected into the patient. These drug ...