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The actions of Δ 9-THC result from its partial agonist activity at the cannabinoid receptor CB 1 (K i = 40.7 nM [24]), located mainly in the central nervous system, and the CB 2 receptor (K i = 36 nM [24]), mainly expressed in cells of the immune system. [25] The psychoactive effects of THC are primarily mediated by the activation of (mostly G ...
Popular strains are often hybrids of C. sativa and C. indica. The medicinal effects of cannabis are widely studied, and are active topics of research both at universities and private research firms. Many jurisdictions have laws regulating or prohibiting the cultivation, sale and/or use of medical and recreational cannabis. [citation needed]
Charlotte's Web was a strain developed by the Stanley brothers (Joel, Jesse, Jon, Jordan, Jared and Josh [12]) through crossbreeding a strain of marijuana with industrial hemp. [13] This process created a variety with less tetrahydrocannabinol (THC) and more cannabidiol (CBD) than typical varieties of marijuana. [ 14 ]
The origins of Kush Cannabis are from landrace plants mainly in Afghanistan, Northern Pakistan and North-Western India [3] with the name coming from the Hindu Kush mountain range. "Hindu Kush" strains of Cannabis were taken to the United States in the mid-to-late 1970s and continue to be available there to the present day.
Cannabis seeds may have been used for food, rituals or religious practices in ancient Europe and China. [82]: 19–22 Harvesting the plant led to the spread of cannabis throughout Eurasia about 10,000 to 5,000 years ago, with further distribution to the Middle East and Africa about 2,000 to 500 years ago. [82]: 18–19 A landrace strain of ...
2008: decriminalized cannabis by 63% vote on Question 2. 1 oz (28 g) or less punishable by $100 fine. [97] [98] 2012: medical marijuana legalized when Question 3 passed by 60%. [99] [100] 2016: legalized recreational marijuana when Question 4 passed by 54%. [101] Michigan: Legal to possess up to 2.5 oz (71 g) in public or 10 oz (280 g) at home