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Genetic variance has three major components: the additive genetic variance, dominance variance, and epistatic variance. [3] Additive genetic variance involves the inheritance of a particular allele from your parent and this allele's independent effect on the specific phenotype, which will cause the phenotype deviation from the mean phenotype.
It is well established that the genetic diversity among human populations is low, [3] although the distribution of the genetic diversity was only roughly estimated. Early studies argued that 85–90% of the genetic variation is found within individuals residing in the same populations within continents (intra-continental populations) and only ...
Two fundamental calculations are central to population genetics: allele frequencies and genotype frequencies. [1] Genotype frequency in a population is the number of individuals with a given genotype divided by the total number of individuals in the population. [ 2 ]
The fixation index (F ST) is a measure of population differentiation due to genetic structure. It is frequently estimated from genetic polymorphism data, such as single-nucleotide polymorphisms (SNP) or microsatellites. Developed as a special case of Wright's F-statistics, it is one of the most commonly used statistics in population genetics ...
In population genetics, the Watterson estimator is a method for describing the genetic diversity in a population. It was developed by Margaret Wu and G. A. Watterson in the 1970s. [1] [2] It is estimated by counting the number of polymorphic sites. It is a measure of the "population mutation rate" (the product of the effective population size ...
In genetics, a polygenic score (PGS) is a number that summarizes the estimated effect of many genetic variants on an individual's phenotype. The PGS is also called the polygenic index (PGI) or genome-wide score; in the context of disease risk, it is called a polygenic risk score (PRS or PR score [1]) or genetic risk score. The score reflects an ...
Nucleotide diversity is a measure of genetic variation. It is usually associated with other statistical measures of population diversity, and is similar to expected heterozygosity . This statistic may be used to monitor diversity within or between ecological populations, to examine the genetic variation in crops and related species, [ 3 ] or to ...
The ACE model is a statistical model commonly used to analyze the results of twin and adoption studies. This classic behaviour genetic model aims to partition the phenotypic variance into three categories: additive genetic variance (A), common (or shared) environmental factors (C), and specific (or nonshared) environmental factors plus ...