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[145] [146] [147] However, a 2017 hybrid systematic review found that the incidence of depression in women treated with spironolactone for acne was less than 1%. [63] Likewise, a 10-year observational study found that the incidence of depression in 196 transgender women taking high-dose spironolactone in combination with an estrogen was less ...
According to a study in JAMA Dermatology, the prescribing rates of spironolactone for acne in women rose about 300% from 2017 to 2020. ... For acne, the dosage is higher: it’s often started at ...
Side effects of spironolactone in clinical studies for acne in women Side effect RCTs Tooltip Randomized controlled trials (n (ITT Tooltip Intention-to-treat analysis) = 326) Case series (n (ITT Tooltip Intention-to-treat analysis) = 663) Number % Number % Menstrual irregularities: 38: 13.4 (of 283) 216: 33.4 (of 646) Breast tenderness: 8: 2.5: ...
Spironolactone: Spironolactone is used to treat high blood pressure but is also prescribed off-label for treating acne in women. Spironolactone reduces the amount of androgen hormones in your body ...
[37] [105] Alone or in combination with a birth control pill, spironolactone has shown a 33 to 85% reduction in acne lesions in women. [116] The effectiveness of spironolactone for acne appears to be dose-dependent. [116] High-dose cyproterone acetate alone reportedly decreases acne symptoms in women by 75 to 90% within three months. [127]
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