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Hypervitaminosis A results from excessive intake of preformed vitamin A. Genetic variations in tolerance to vitamin A intake may occur, so the toxic dose will not be the same for everyone. [23] Children are particularly sensitive to vitamin A, with daily intakes of 1500 IU/kg body weight reportedly leading to toxicity. [21]
In the 1930s and 1940s, some scientific and clinical evidence suggested that there might be beneficial uses of vitamins C, E, and niacin in large doses. Beginning in the 1930s in Canada, a megadose vitamin E therapy for cardiovascular and circulatory complaints was developed by Evan Shute and colleagues, named the "Shute protocol". [15]
[33] [32] According to the U.S. Food and Drug Administration (FDA), high-dose vitamin C (such as intravenous ascorbic acid therapy) has not been approved as a treatment for cancer or any other medical condition. [2] There many been multiple studies devoted to investigating the medicinal properties of ascorbic acid.
The CDC recommends daily doses of vitamin A at 50,000 IU for infants younger than 6 months of age, 100,000 IU for infants 6 to 11 months of age, and 200,000 IU for children 12 months of age and older.
Adding to the concern is that vitamin A is toxic at high levels. It’s a fat-soluble vitamin, so it’s stored in the body instead of released through urine. The more you take, the more it ...
High doses can even be toxic. “There’s not evidence that vitamin A has any preventative benefits,” said Dr. Peter Hotez, co-director of the Center for Vaccine Development at Texas Children ...
Vitamin C megadosage is a term describing the consumption or injection of vitamin C (ascorbic acid) in doses well beyond the current United States Recommended Dietary Allowance of 90 milligrams per day, and often well beyond the tolerable upper intake level of 2,000 milligrams per day. [1]
Hypervitaminosis is a condition of abnormally high storage levels of vitamins, which can lead to various symptoms as over excitement, irritability, or even toxicity. Specific medical names of the different conditions are derived from the given vitamin involved: an excess of vitamin A, for example, is called hypervitaminosis A.