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  2. Rivaroxaban - Wikipedia

    en.wikipedia.org/wiki/Rivaroxaban

    Accordingly, rivaroxaban was studied for any possible antimicrobial effects and for the possibility of mitochondrial toxicity, which is a known complication of long-term linezolid use. [40] Studies found that neither rivaroxaban nor its metabolites have any antibiotic effect against Gram-positive bacteria.

  3. Andexanet alfa - Wikipedia

    en.wikipedia.org/wiki/Andexanet_alfa

    Andexanet alfa, sold under the brand name Andexxa among others, is an antidote for the medications rivaroxaban and apixaban, when reversal of anticoagulation is needed due to uncontrolled bleeding. [8] It has not been found to be useful for other factor Xa inhibitors. [9] It is given by injection into a vein. [9]

  4. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    Antistasin, the first discovered naturally occurring direct Xa inhibitor Rivaroxaban, the first synthetic direct Xa inhibitor marketed as a drug Prior to the introduction of direct factor Xa inhibitors, vitamin K antagonists such as warfarin were the only oral anticoagulants for over 60 years, and together with heparin have been the main blood ...

  5. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Rivaroxaban. During the SAR development of rivaroxaban, researchers realized that adding a 5-chlorothiophene-2-carboxamide group to the oxazolidonine core could increase the potency by 200 fold, which had previously been too weak for medical use. In addition to this discovery, a clear preference for the (S)-configuration was confirmed.

  6. Man Suggests Ex-Girlfriend's Name for Baby with New Wife ...

    www.aol.com/man-suggests-ex-girlfriends-name...

    In a post shared on Reddit, the anonymous, 40-year-old man writes that he and his wife, Anna, recently had a baby girl. "During the pregnancy we had settled on the name Elizabeth," he writes.

  7. Nearly 30% of US drugstores closed in one decade, study shows

    www.aol.com/nearly-30-us-drugstores-closed...

    Nearly three out of 10 U.S. drugstores that were open during the previous decade had closed by 2021, new research shows. Black and Latino neighborhoods were most vulnerable to the retail pharmacy ...

  8. Super Micro's shares jump after server maker says review ...

    www.aol.com/super-micros-shares-jump-server...

    Just over a month after Ernst & Young resigned as its public accounting firm, Super Micro Computer says a review committee has found no evidence of fraud or misconduct among the server maker’s ...

  9. Ethinylestradiol/etonogestrel - Wikipedia

    en.wikipedia.org/wiki/Ethinylestradiol/etonogestrel

    A study in The BMJ, with over 1.6 million women, found that users of vaginal rings with ethinylestradiol and etonogestrel have a 6.5 times increased risk of venous thrombosis compared to non-users. [ 19 ] [ 20 ] Epidemiological studies have shown that oral contraceptives that contain desogestrel can increase the risk of blood clots (venous ...

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