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Most clinical studies recommend the use of HbA1c assays that are traceable to the DCCT assay. [55] The National Glycohemoglobin Standardization Program (NGSP) and IFCC have improved assay standardization. [37] For initial diagnosis of diabetes, only HbA1c methods that are NGSP-certified should be used, not point-of-care testing devices. [36]
On average, each change of 3.3 mmol (60 mg/dL) in average blood sugar levels will give rise to changes of 2% HbA1c and 75 μmol fructosamine values. [6] However, this overemphasizes the upper limit of many laboratories' reference ranges of 285 μmol/L as equivalent to HbA1c 7.5% rather than 6.5%.
Chronic hyperglycemia can be measured via the HbA1c test. The definition of acute hyperglycemia varies by study, with mmol/L levels from 8 to 15 (mg/dL levels from 144 to 270). [48] Defects in insulin secretion, insulin action, or both, results in hyperglycemia. [16]
So that brings us to another type of test that can be done which is the HbA1c test, which tests for the proportion of hemoglobin in red blood cells that has glucose stuck to it - called glycated hemoglobin. HbA1c levels of 5.7% to 6.4% indicates prediabetes, and 6.5% or higher indicates diabetes.
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The IFCC's aims are to set global standards, support and educate its members, and provide conferences and other gatherings for sharing knowledge among the global laboratory medicine community. [ 1 ] IFCC members fall into three groups: national societies of clinical chemistry and laboratory medicine, corporations , and affiliate international ...
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