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In S. cerevisiae mitochondria, phosphatidylcholine makes up 38.4% of the IMM, phosphatidylethanolamine makes up 24.0%, phosphatidylinositol 16.2%, cardiolipin 16.1%, phosphatidylserine 3.8%, and phosphatidic acid 1.5%. [6] In the inner mitochondrial membrane, the protein-to-lipid ratio is 80:20, in contrast to the outer membrane, which is 50:50 ...
IMMT encodes an inner mitochondrial membrane (IMM) protein in the nucleus. It is posttranslational transported to the IMM. It is posttranslational transported to the IMM. Mic60/Mitofilin (encoded by the IMMT gene) is a core subunit of the MICOS-complex, directly located next to cristae junctions (CJ).
In the mitochondrion, the matrix is the space within the inner membrane. The word "matrix" stems from the fact that this space is viscous, compared to the relatively aqueous cytoplasm. The mitochondrial matrix contains the mitochondrial DNA, ribosomes, soluble enzymes, small organic molecules, nucleotide cofactors, and inorganic ions. [1]
67013 Ensembl ENSG00000162600 ENSMUSG00000035069 UniProt Q96E52 Q9D8H7 RefSeq (mRNA) NM_145243 NM_025909 RefSeq (protein) NP_660286 NP_080185 Location (UCSC) Chr 1: 58.42 – 58.55 Mb Chr 4: 103.17 – 103.23 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Metalloendopeptidase OMA1, mitochondrial is an enzyme that in humans is encoded by the OMA1 gene. OMA1 is a Zn 2+ -dependent ...
During the mid-to-late 1960s, several independent laboratories claimed they had successfully separated the outer mitochondrial membrane and inner mitochondrial membrane. In March 1967, a team of researchers from the Nutritional Physiology Laboratory in France published an article that discussed their studies of the enzymatic activities of the ...
Then they are transported across the inner mitochondrial membrane into the matrix and converted into the acetyl CoA to enter the citric acid cycle. [7] [8] Apoptotic components released from the intermembrane space of a mitochondrion. The respiratory chain in the inner mitochondrial membrane carries out oxidative phosphorylation.
The carrier preprotein is then inserted into the inner mitochondrial membrane in a potential-dependent fashion. [10] The membrane potential is necessary for both insertion of the precursor into the carrier translocase and lateral release of the protein into the lipid phase of the inner mitochondrial membrane, which completes protein translocation.
The citrate-malate shuttle is a series of chemical reactions, commonly referred to as a biochemical cycle or system, that transports acetyl-CoA in the mitochondrial matrix across the inner and outer mitochondrial membranes for fatty acid synthesis. [1] Mitochondria are enclosed in a double membrane. As the inner mitochondrial membrane is ...