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The inner mitochondrial membrane is both an electrical insulator and chemical barrier. Sophisticated ion transporters exist to allow specific molecules to cross this barrier. There are several antiport systems embedded in the inner membrane, allowing exchange of anions between the cytosol and the mitochondrial matrix. [7]
Mitochondrial import inner membrane translocase subunit Tim9 B is an enzyme that in humans is encoded by the FXC1 gene. [ 5 ] [ 6 ] FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space.
Tim9 and Tim10 make up the group of essential small Tim proteins that assist in transport of hydrophobic precursors across the intermembrane space in mammalian cells. Both Tim9 and Tim10 form a hexamer, the Tim9-Tim10 complex, that when associated, functions as a chaperone to assist translocation of preproteins from the outer mitochondrial membrane to the translocase of the inner membrane.
30059 Ensembl ENSG00000134809 ENSMUSG00000027076 UniProt P62072 P62073 RefSeq (mRNA) NM_012456 NM_013899 RefSeq (protein) NP_036588 NP_038927 Location (UCSC) Chr 11: 57.53 – 57.53 Mb Chr 2: 84.66 – 84.66 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mitochondrial import inner membrane translocase subunit Tim10 is an enzyme that in humans is encoded by the TIMM10 gene. TIMM10 ...
IMMT encodes an inner mitochondrial membrane (IMM) protein in the nucleus. It is posttranslational transported to the IMM. It is posttranslational transported to the IMM. Mic60/Mitofilin (encoded by the IMMT gene) is a core subunit of the MICOS-complex, directly located next to cristae junctions (CJ).
Mitochondria is a double-membrane structure in the body cell that generates and transports essential metabolic products. The three layers of this structure are the outer membrane, intermembrane space, and inner membrane. [2] The space inside the mitochondria is called the mitochondrial matrix, while the region outside is the cytosol.
30055 Ensembl ENSG00000099800 ENSMUSG00000020219 UniProt Q9Y5L4 P62075 RefSeq (mRNA) NM_012458 NM_013895 RefSeq (protein) NP_036590 NP_038923 Location (UCSC) Chr 19: 2.43 – 2.43 Mb Chr 10: 80.74 – 80.74 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mitochondrial import inner membrane translocase subunit Tim13 is an enzyme that in humans is encoded by the TIMM13 gene. Function ...
The TIMM50 gene is located on the q arm of chromosome 19 in position 13.2 and spans 13,373 base pairs. [6] The gene produces a 39.6 kDa protein composed of 353 amino acids. [10] [11] This gene encodes a subunit of the TIM23 inner mitochondrial membrane translocase complex, which mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.