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A close analog of a stapled peptide drug invented in the Verdine Lab, sulanemadlin (ALRN-6924), is a first-in-class dual MDM2/MDMX inhibitor currently in Phase II clinical development by Aileron Therapeutics, [4] which he co-founded in 2005. FogPharma, founded in 2016, aims to further develop stapled peptide technology for therapeutic use.
She held a number of patents for modified peptides in the treatment of psoriasis, Alzheimer's disease, chronic fatigue syndrome, stroke and head trauma. One of her modified peptides, Peptide T, had been considered for the treatment of AIDS and neuroAIDS. A placebo-controlled, three-site, 200+ patient NIH-funded clinical trial which was ...
Ribbon schematic of Triosephosphate isomerase, hand-drawn by Jane Richardson All-atom contact dots for two well-packed Ala residues. Jane Shelby Richardson (born January 25, 1941) [1] [2] is an American biophysicist best known for developing the Richardson diagram, or ribbon diagram, a method of representing the 3D structure of proteins. [3]
Modern Woman: The Lost Sex portrays the feminist movement not as a response to centuries-long subjugation of women, but rather as a misguided attempt to remedy the female population's lack of clear purpose after the Industrial Revolution forced them and their economic productivity out of the home. The authors argue that while feminism claims to ...
A quick but important note about biohacking. While the $27 billion longevity market is embraced by many, its specific practices are not always scientifically backed, FDA-approved or physician ...
Finally, I started her on a relatively new injectable drug called Gattex (teduglutide), an analogue of a human hormone secreted by intestinal cells known as glucagon-like peptide-2 (GLP-2).
Her most-famous contribution to modern physics was discovering the nuclear shell of the atomic nucleus, for which she won the Nobel Prize in 1963. Slow light Lene Hau led a Harvard University team who used a Bose–Einstein condensate to slow down a beam of light to about 17 metres per second , and, in 2001, was able to stop a beam completely.
The modern all-volunteer military was born in the post-Vietnam years and has struggled to recruit men due to its dangerous and unpopular nature. However, women have flooded into the service and ...
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