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These calcium ions are responsible for the contraction of the heart. Calcium also activates chloride channels called I to2 , which allow Cl − to enter the cell. Increased calcium concentration in the cell also increases activity of the sodium-calcium exchangers, while increased sodium concentration (from the depolarisation of phase 0 ...
Depolarization propagates through cardiac muscle very rapidly. Cells of the ventricles contract nearly simultaneously. The action potentials of cardiac muscle are unusually sustained. This prevents premature relaxation, maintaining initial contraction until the entire myocardium has had time to depolarize and contract. Absence of tetany.
The increase in Ca 2+, produced by CICR, now does two things. Firstly, it binds to the intracellular side of the DHPR, signalling the channels to close and preventing further influx of Ca 2+ into the cell. Secondly Ca 2+ indirectly activates proteins, called myofilaments, resulting in muscle contraction.
The main role of a sinoatrial node cell is to initiate action potentials of the heart that can pass through cardiac muscle cells and cause contraction. An action potential is a rapid change in membrane potential, produced by the movement of charged atoms .
An increase in sympathetic stimulation to the heart increases contractility and heart rate. An increase in contractility tends to increase stroke volume and thus a secondary increase in preload. An increase in preload results in an increased force of contraction by Starling's law of the heart; this does not require a change in contractility.
Cardiac muscle tissue has autorhythmicity, the unique ability to initiate a cardiac action potential at a fixed rate – spreading the impulse rapidly from cell to cell to trigger the contraction of the entire heart. This autorhythmicity is still modulated by the endocrine and nervous systems. [1]
It employs pacemaker cells that produce electrical impulses, known as cardiac action potentials, which control the rate of contraction of the cardiac muscle, that is, the heart rate. In most humans, these cells are concentrated in the sinoatrial (SA) node, the primary pacemaker, which regulates the heart’s sinus rhythm.
A neutrino (/ nj uː ˈ t r iː n oʊ / new-TREE-noh; denoted by the Greek letter ν) is an elementary particle that interacts via the weak interaction and gravity. [2] [3] The neutrino is so named because it is electrically neutral and because its rest mass is so small that it was long thought to be zero.
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