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Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum that dismantles collagen.It is used as a powder-and-solvent injection kit for the treatment of Dupuytren's contracture, a condition where the fingers bend towards the palm and cannot be fully straightened, and Peyronie's disease, a connective tissue disorder involving the growth of fibrous ...
Peyronie’s disease is sometimes called “curved privates disease” or simply “curvature” because the scar tissue (or plaque) causes the privates to bend when aroused. ... Xiaflex is the ...
Peyronie's disease is a connective tissue disorder involving the growth of fibrous plaques in the soft tissue of the penis. Specifically, scar tissue forms in the tunica albuginea , the thick sheath of tissue surrounding the corpora cavernosa , causing pain, abnormal curvature, erectile dysfunction , indentation, loss of girth and shortening.
This expanded Endo's portfolio to include 12 additional products, including a variery of testosterone preparations, and Xiaflex (a treatment for Peyronie's disease) [30] [31] In the same year they also acquired Dava Pharmaceuticals. [32] [33] 2015: Endo acquired the specialty generics and sterile injectables company Par Pharmaceutical for $8.05 ...
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In severe cases, the area where the palm meets the wrist may develop lumps. It is thought the condition Peyronie's disease is related to Dupuytren's contracture. [17] In one study those with stage 2 of the disease were found to have a slightly increased risk of mortality, especially from cancer. [18]
This group of metallopeptidases constitutes the MEROPS peptidase family M9, subfamilies M9A and M9B (microbial collagenase, clan MA(E)). The protein fold of the peptidase domain for members of this family resembles that of thermolysin, the type example for clan MA and the predicted active site residues for members of this family and thermolysin occur in the motif HEXXH.
A penis extender is an external medical device with tentative evidence as of 2019 for Peyronie's disease. It acts as a mechanical, traction device that stretches the human penis in the flaccid state to make it longer. [1]