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In addition, clonazepam decreases the utilization of 5-HT (serotonin) by neurons [115] [116] and has been shown to bind tightly to central-type benzodiazepine receptors. [117] Because clonazepam is effective in low milligram doses (0.5 mg clonazepam = 10 mg diazepam), [118] [119] it is said to be among the class of "highly potent ...
Clinical Pharmacology - tells how the medicine works in the body, how it is absorbed and eliminated, and what its effects are likely to be at various concentrations. May also contain results of various clinical trials (studies) and/or explanations of the medication's effect on various populations (e.g. children, women, etc.).
Cloniprazepam is a benzodiazepine derivative and a prodrug of clonazepam, 7-aminoclonazepam, and other metabolites. [ 1 ] [ 2 ] Some of the minor metabolites include 3-hydroxyclonazepam and 6-hydroxyclonazepam , 3-hydroxycloniprazepam and ketocloniprazepam with ketone group formed where 3-hydroxy group was.
Clonazepam, a benzodiazepine is used to treat many forms of parasomnia. [77] Rapid eye movement behavior disorder responds well to low doses of clonazepam. [78] [79] Restless legs syndrome can be treated using clonazepam as a third line treatment option as the use of clonazepam is still investigational. [80] [81]
Clonazepam ODT blister pack and tablet Etizest-1 MD (Etizest-brand 1mg-doskk etizolam mouth-dissolving (MD) blister pack and opened tablet. An orally disintegrating tablet or orally dissolving tablet (ODT) is a drug dosage form available for a limited range of over-the-counter (OTC) and prescription medications.
A 1985 study found that triazolam and temazepam maintained higher rates of self-injection in both human and animal subjects compared to a variety of other benzodiazepines (others examined: diazepam, lorazepam, oxazepam, flurazepam, alprazolam, chlordiazepoxide, clonazepam, nitrazepam, flunitrazepam, bromazepam, and clorazepate). [7]
A sedative or tranquilliser [note 1] is a substance that induces sedation by reducing irritability [1] or excitement. [2] They are central nervous system (CNS) depressants and interact with brain activity causing its deceleration.
Meclonazepam [1] ((S)-3-methylclonazepam) was discovered by a team at Hoffmann-La Roche in the 1970s and is a drug which is a benzodiazepine derivative similar in structure to clonazepam. [2] It has sedative and anxiolytic actions like those of other benzodiazepines, [3] and also has anti-parasitic effects against the parasitic worm Schistosoma ...