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In addition, clonazepam decreases the utilization of 5-HT (serotonin) by neurons [115] [116] and has been shown to bind tightly to central-type benzodiazepine receptors. [117] Because clonazepam is effective in low milligram doses (0.5 mg clonazepam = 10 mg diazepam), [118] [119] it is said to be among the class of "highly potent ...
In the European Union, the European Medicines Agency has jurisdiction and the relevant documents are called the "summary of product characteristics" (SPC or SmPC) and the document for end-users is called the "patient information leaflet" or "package leaflet". The SPC is not intended to give general advice about treatment of a condition but does ...
Clonazepam, a benzodiazepine is used to treat many forms of parasomnia. [77] Rapid eye movement behavior disorder responds well to low doses of clonazepam. [78] [79] Restless legs syndrome can be treated using clonazepam as a third line treatment option as the use of clonazepam is still investigational. [80] [81]
Clobazam was first synthesized in 1966 and first published in 1969. Clobazam was originally marketed as an anxioselective anxiolytic since 1970, [4] [5] and an anticonvulsant since 1984. [6] The primary drug-development goal was to provide greater anxiolytic, anti-obsessive efficacy with fewer benzodiazepine-related side effects. [4]
Some of the symptoms that could possibly occur as a result of a withdrawal from benzodiazepines after long-term use include emotional clouding, [1] flu-like symptoms, [5] suicide, [11] nausea, headaches, dizziness, irritability, lethargy, sleep problems, memory impairment, personality changes, aggression, depression, social deterioration as ...
This work is in the public domain in the United States because it is a work prepared by an officer or employee of the United States Government as part of that person’s official duties under the terms of Title 17, Chapter 1, Section 105 of the US Code.
An Australian study (2004) of overdose admissions between 1987 and 2002 found alprazolam, which happens to be the most prescribed benzodiazepine in Australia and the United States, to be more toxic than diazepam and the other three benzodiazepines which it was compared to (alprazolam, diazepam, oxazepam, chlordiazepoxide, and clonazepam).
Chlordiazepoxide was patented in 1958 and approved for medical use in 1960. [5] It was the first benzodiazepine to be synthesized and the discovery of chlordiazepoxide was by pure chance. [ 6 ] Chlordiazepoxide and other benzodiazepines were initially accepted with widespread public approval, but were followed with widespread public disapproval ...