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In addition, clonazepam decreases the utilization of 5-HT (serotonin) by neurons [115] [116] and has been shown to bind tightly to central-type benzodiazepine receptors. [117] Because clonazepam is effective in low milligram doses (0.5 mg clonazepam = 10 mg diazepam), [118] [119] it is said to be among the class of "highly potent ...
The Catholic Bible contains 73 books; the additional seven books are called the Apocrypha and are considered canonical by the Catholic Church, but not by other Christians. When citing the Latin Vulgate , chapter and verse are separated with a comma, for example "Ioannem 3,16"; in English Bibles chapter and verse are separated with a colon, for ...
Cloniprazepam is a benzodiazepine derivative and a prodrug of clonazepam, 7-aminoclonazepam, and other metabolites. [ 1 ] [ 2 ] Some of the minor metabolites include 3-hydroxyclonazepam and 6-hydroxyclonazepam , 3-hydroxycloniprazepam and ketocloniprazepam with ketone group formed where 3-hydroxy group was.
Such editions, which typically use thematic or literary criteria to divide the biblical books instead, include John Locke's Paraphrase and Notes on the Epistles of St. Paul (1707), [11] Alexander Campbell's The Sacred Writings (1826), [12] Daniel Berkeley Updike's fourteen-volume The Holy Bible Containing the Old and New Testaments and the ...
Ro05-4082 (N-methylclonazepam, ID-690) is a benzodiazepine derivative developed in the 1970s. It has sedative and hypnotic properties, and has around the same potency as clonazepam itself. [1]
Evidence from reviews of benzodiazepine tolerance mechanisms [42] and clonazepam use in psychiatric disorders [43] is strongly discordant with the claim that benzodiazepines lose anxiolytic efficacy over a period of weeks, as these reviews present RCT evidence of continued anxiolytic efficacy at up to 22 weeks [44] and observational (open-label ...
Matthew 5:22 is the twenty-second verse of the fifth chapter of the Gospel of Matthew in the New Testament and is part of the Sermon on the Mount. It is the first of what have traditionally been known as the 6 Antitheses .
Chlordiazepoxide was patented in 1958 and approved for medical use in 1960. [5] It was the first benzodiazepine to be synthesized and the discovery of chlordiazepoxide was by pure chance. [ 6 ] Chlordiazepoxide and other benzodiazepines were initially accepted with widespread public approval, but were followed with widespread public disapproval ...