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Chlorpromazine (CPZ), marketed under the brand names Thorazine and Largactil among others, is an antipsychotic medication. [6] It is primarily used to treat psychotic disorders such as schizophrenia . [ 6 ]
ECG changes [Note 4]; Contact dermatitis; Sensitivity to light; Urticaria (hives); Maculopapular rash; Petechia or edema; Hyperprolactinaemia [Note 5]; Impaired thermoregulation [Note 6] ...
A related concept to D2 potency is the concept of "chlorpromazine equivalence", which provides a measure of the relative effectiveness of antipsychotics. [ 13 ] [ 14 ] The measure specifies the amount (mass) in milligrams of a given drug that must be administered in order to achieve desired effects equivalent to those of 100 milligrams of ...
Simone Courvoisier was a French experimental pharmacologist who, while the head of pharmacology at Rhône-Poulenc in the 1950s, investigated the use of the antipsychotic medication chlorpromazine. [ 1 ] [ 2 ] She discovered that the compound promazine had sedating properties despite not being an antihistamine like its precursor promethazine ...
Jean Delay (14 November 1907, Bayonne – 29 May 1987, Paris) was a French psychiatrist, neurologist, writer, and a member of the Académie française (Chair 17).. His assistant Pierre Deniker conducted a test of chlorpromazine on the male mental ward where Delay worked, and the two published their findings (quickly, with what has been called academic gamesmanship) in 1952. [1]
It acts similar to chlorpromazine and causes sedation. [3] It has predominantly anticholinergic side effects, though extrapyramidal side effects are not uncommon. It belongs to the typical antipsychotic and phenothiazine class of drugs. [5]
Prochlorperazine is analogous to chlorpromazine; both of these agents antagonize dopaminergic D 2 receptors in various pathways of the central nervous system. This D 2 blockade results in antipsychotic, antiemetic and other effects.
Chlorpromazine, derived from promethazine originally as a sedative, was found to have neuroleptic properties in the early 1950s, and was the first typical antipsychotic. Imipramine , originally investigated as an antipsychotic, was discovered in the early 1950s, and was the first tricyclic antidepressant .