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The area under the effect curve (AUEC) is an integral of the effect of a drug over time, estimated as a previously-established function of concentration. It was proposed to be used instead of AUC in animal-to-human dose translation, as computer simulation shows that it could cope better with half-life and dosing schedule variations than AUC.
A 2016 Science paper reports that the trapezoid rule was in use in Babylon before 50 BCE for integrating the velocity of Jupiter along the ecliptic. [1]In 1994, a paper titled "A Mathematical Model for the Determination of Total Area Under Glucose Tolerance and Other Metabolic Curves" was published, only to be met with widespread criticism for rediscovering the Trapezoidal Rule and coining it ...
A line integral (sometimes called a path integral) is an integral where the function to be integrated is evaluated along a curve. [42] Various different line integrals are in use. In the case of a closed curve it is also called a contour integral. The function to be integrated may be a scalar field or a vector field.
The term "numerical integration" first appears in 1915 in the publication A Course in Interpolation and Numeric Integration for the Mathematical Laboratory by David Gibb. [2] "Quadrature" is a historical mathematical term that means calculating area. Quadrature problems have served as one of the main sources of mathematical analysis.
To estimate the area under a curve the trapezoid rule is applied first to one-piece, then two, then four, and so on. One-piece. Note since it starts and ends at zero, this approximation yields zero area. Two-piece Four-piece Eight-piece. After trapezoid rule estimates are obtained, Richardson extrapolation is applied.
In qualitative terms, a line integral in vector calculus can be thought of as a measure of the total effect of a given tensor field along a given curve. For example, the line integral over a scalar field (rank 0 tensor) can be interpreted as the area under the field carved out by a particular curve.
Approximating the area under the curve y = x 2 over [0, 2] using the right Riemann sum. Notice that because the function is monotonically increasing, the right Riemann sum will always overestimate the area contributed by each term in the sum (and do so maximally).
A different technique, which goes back to Laplace (1812), [3] is the following. Let = =. Since the limits on s as y → ±∞ depend on the sign of x, it simplifies the calculation to use the fact that e −x 2 is an even function, and, therefore, the integral over all real numbers is just twice the integral from zero to infinity.