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Ovarian hyperstimulation syndrome (OHSS) is a medical condition that can occur in some women who take fertility medication to stimulate egg growth, and in other women in sporadic cases. Most cases are mild, but rarely the condition is severe and can lead to serious illness or even death.
Induction of final maturation (such as done with hCG) may need to be withheld because of increased risk of ovarian hyperstimulation syndrome. [26] The starting dose of the inducing drug should be reduced in the next cycle. [26] Alternatives to cancelling a cycle are mainly: Aspiration of supernumerary follicles until one or two remain. [26] [27]
According to NICE guidelines of in vitro fertilization, an anti-Müllerian hormone level of less than or equal to 5.4 pmol/L (0.8 ng/mL) predicts a low response to ovarian hyperstimulation, while a level greater than or equal to 25.0 pmol/L (3.6 ng/mL) predicts a high response. [8]
Why does ovarian hyperstimulation syndrome occur? OHSS is a potential side effect of stimulating the ovaries to produce multiple eggs at the same time either during the first part of an IVF cycle ...
Common side effects include ovarian enlargement, hot flash, abdominal distention, breast discomfort, and hyperlipidemia. Rare adverse effects are ovarian hyperstimulation syndrome and visual abnormalities. [13] Long-term use may raise risk of ovarian cancer, such that long-term therapy (more than 6 cycles) is not recommended. [13] [14]
Although metformin has been used off-label to treat oligomenorrhea and ovarian hyperstimulation syndrome (OHSS) in women with PCOS, metformin is no longer recommended as infertility treatment per the American Society for Reproductive Medicine (ASRM) in 2017. Its use to treat anovulatory infertility was based on an association of insulin ...
Theca lutein cyst is a type of bilateral functional ovarian cyst filled with clear, straw-colored fluid. These cysts result from exaggerated physiological stimulation (hyperreactio luteinalis) due to elevated levels of beta-human chorionic gonadotropin (beta-hCG) or hypersensitivity to beta-hCG.
Surgical treatment options include colpocleisis, vaginal reconstruction, and abdominal sacrocolpopexy. Colpocleisis is an obliterative procedure that would remove the possibility of vaginal intercourse. Therefore, a person's desire to get pregnant is considered when deciding treatment for this condition. [20]