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Researchers have published conflicting reports concerning whether Blastocystis causes symptoms in humans, with one of the earliest reports in 1916. [2] The incidence of reports associated with symptoms began to increase in 1984, [3] with physicians from Saudi Arabia reporting symptoms in humans [4] and US physicians reporting symptoms in individuals with travel to less developed countries. [5]
In the early 2000s, Egyptian physicians identified 84 patients with diarrhea and enteritis apparently caused by Blastocystis hominis. After three days of nitazoxanide treatment, symptoms cleared and no fecal organisms were detectable in 36 (86%) of 42 treated patients and in 16 (38%) of 42 people who received placebo (P < .0001).
Blastocystis hominis is a single-celled eukaryotic organism that inhabits the gastrointestinal tract of humans and various animals. [1] This stramenopile exhibits significant genetic diversity and has become an organism of increasing scientific interest due to its widespread distribution and controversial role in human health. [ 2 ]
Melarsoprol (for treatment of sleeping sickness caused by Trypanosoma brucei) Eflornithine (for sleeping sickness) Metronidazole (for vaginitis caused by Trichomonas) Tinidazole (for intestinal infections caused by Giardia lamblia) Miltefosine (for the treatment of visceral and cutaneous leishmaniasis, currently undergoing investigation for ...
pimobendan – phosphodiesterase 3 inhibitor used to manage heart failure in dogs; pirlimycin – antimicrobial; ponazuril – anticoccidial; praziquantel – treatment of infestations of the tapeworms Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus; prazosin – sympatholytic used in hypertension and abnormal muscle contractions
It is particularly used for infections of the skin, respiratory system and mammary glands in dogs and cats, as well as with urinary tract infections. For dogs, a dose ranges from 2.75 - 5.5 mg/kg once a day. The duration of treatment is usually at least five days, longer if there is a concurrent fungal or yeast infection. [4]
For treatment against roundworms, drugs based on emodepside, fenbendazole, flubendazole, mebendazole, milbemycin oxime, moxidectin, pyrantel and selamectin are approved in Germany for domestic dogs. These drugs are broad-spectrum anthelmintics and also exert activity against most other nematodes found in dogs. [ 70 ]
However, treatment should be short, meaning a single injection daily for about a week. Treatment should only be given by prescription. Cefquinome should not be used in feed or water. Since 1994, in Europe, it was allowed to treat cattle by prescription only. In 1999, swine were included. By 2005, horses were allowed as well.
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