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The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
Symptoms of schizophrenia often appear soon after puberty, when the brain is undergoing significant maturational changes. Some investigators believe that the disease process of schizophrenia begins prenatally, remains dormant until puberty, then follows a period of neural degeneration that causes the symptoms to subsequently emerge. [13]
The Kraepelinian dichotomy is made questionable [clarification needed] by grey matter abnormalities in bipolar and schizophrenia; schizophrenia is distinguishable from bipolar in that regions of grey matter reduction are generally larger in magnitude, although adjusting for gender differences reduces the difference to the left dorsomedial ...
The causes of schizophrenia may include genetic and environmental factors. [7] Genetic factors include a variety of common and rare genetic variants . [ 21 ] Possible environmental factors include being raised in a city , childhood adversity, cannabis use during adolescence, infections, the age of a person's mother or father , and poor ...
The parahippocampal gyrus (or hippocampal gyrus [1]) is a grey matter cortical region of the brain that surrounds the hippocampus and is part of the limbic system. The region plays an important role in memory encoding and retrieval. It has been involved in some cases of hippocampal sclerosis. [2] Asymmetry has been observed in schizophrenia. [3]
Abnormal expression, thus distribution of the D 2 receptor between these areas and the rest of the brain may also be implicated in schizophrenia, specifically in the acute phase. A relative excess of these receptors within the limbic system means Broca's area , which can produce illogical language, has an abnormal connection to Wernicke's area ...
These rapid evolutionary changes, in some cases, may impede normal development within the social brain. [14] [15] As schizophrenia is foremost a disorder of the consciousness, it has been suggested that schizophrenia exists as an unwanted byproduct of the evolution of the prefrontal cortex and other brain regions constituting the social brain. [13]
The categories of dark matter are set with respect to the size of a protogalaxy (an object that later evolves into a dwarf galaxy): dark matter particles are classified as cold, warm, or hot if their FSL is much smaller (cold), similar to (warm), or much larger (hot) than a protogalaxy.
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