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High-dose biotin (300 mg/day = 10,000 times adequate intake) has been used in clinical trials for treatment of multiple sclerosis, a demyelinating autoimmune disease. [37] [38] The hypothesis is that biotin may promote remyelination of the myelin sheath of nerve cells, slowing or even reversing neurodegeneration. The proposed mechanisms are ...
The formula included 1000 μg of cyanocobalamin. This came to be known as the Myers' cocktail . After his death in 1984, other physicians and naturopaths took up prescribing "intravenous micro-nutrient therapy" with unsubstantiated health claims for treating fatigue, low energy, stress, anxiety, migraine, depression, immunocompromised ...
Animals, including humans, can convert cyanocobalamin to any one of the active vitamin B 12 compounds. [21] Cyanocobalamin is one of the most widely manufactured vitamers in the vitamin B 12 family (the family of chemicals that function as B 12 when put into the body), because cyanocobalamin is the most air-stable of the B 12 forms. [22]
Biotin supplements are commonly used in doses of up to 2.5 milligrams (mg) daily for up to 15 months. The maximum dose often recommended is 300 mg daily for up to six months.
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Methylcobalamin (mecobalamin, MeCbl, or MeB 12) is a cobalamin, a form of vitamin B 12. It differs from cyanocobalamin in that the cyano group at the cobalt is replaced with a methyl group. [1] Methylcobalamin features an octahedral cobalt (III) centre and can be obtained as bright red crystals. [2] From the perspective of coordination ...
Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body. [1][7][2] One nanogram per millilitre (1 ng/mL) is equivalent to 2.5 nanomoles per litre (2.5 nmol/L). Severe deficiency: <12 ng/mL = <30 nmol/L[2] Deficiency ...
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