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Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. [ 1 ][ 2 ] Effects of menopause can include symptoms such as hot flashes, accelerated skin aging, vaginal dryness, decreased muscle mass, and ...
Further studies have shown other possible benefits to HRT, such as reduced risk of type 2 diabetes, reduced risk of bone loss and fracture and lower rates of breast cancer when using estrogen-only ...
The timing hypothesis, gap hypothesis, gap theory, or critical window hypothesis for menopausal hormone therapy is a scientific theory that the benefits and risks of menopausal hormone therapy vary depending on the amount of time a woman has been in menopause upon initiation of treatment. [1][2][3][4][5] More specifically, it is thought that ...
Women's Health, Osteoporosis, Progestin, Estrogen (Women's HOPE) Women's International Study of Long-Duration Oestrogen After Menopause (WISDOM) Observational studies. CECILE (French study) Combined Cohorts of Menopausal Women, studies of Register Based Health Outcomes in Relation to Hormonal Drugs (COMPREHEND) Estrogen and Thromboembolism Risk ...
The incidence of hip fractures increases each decade from the sixth through the ninth for both women and men for all populations. The highest incidence is found among men and women ages 80 or older. [177] Between 35 and 50% of all women over 50 had at least one vertebral fracture. In the United States, 700,000 vertebral fractures occur annually ...
To be properly double blinded, the study required that women not be perimenopausal or have symptoms of menopause. As the average age of menopause is 51, this resulted in an older study population, with an average age of 63. Only 3.5% of the women were 50–54 years of age, the time when women usually decide whether to initiate hormonal therapy.
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