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Miconazole, sold under the brand name Monistat among others, is an antifungal medication used to treat ring worm, pityriasis versicolor, and yeast infections of the skin or vagina. [2] It is used for ring worm of the body , groin (jock itch), and feet (athlete's foot). [ 2 ]
The four classes of topical antifungal drugs are azole antifungals, polyene antifungals, allylamine antifungals, and other antifungals. Azole antifungals inhibit the enzyme that converts lanosterol into ergosterol. Common examples of azole antifungals include clotrimazole, econazole, ketoconazole, miconazole, and tioconazole.
Topical clotrimazole is categorized as pregnancy category B. [15] Small amounts of clotrimazole may be absorbed systemically following topical and vaginal administration. However, topical clotrimazole is still considered safe to use to treat yeast infections in pregnant women and is a safer alternative to other antifungals. [15] [16]
Oral ketoconazole is indicated for use in these countries when the indication is a severe or life-threatening systemic infection and alternatives are unavailable. [18] However, topical ketoconazole, which does not distribute systemically, is safe and widely used still. [18]
In fact, 1 in 10 people are affected, and for those over 70, this statistic jumps to 1 in 2. Toenail fungus starts innocently enough, appearing as a small white or yellow spot under the tip of ...
In addition to other formulations, ciclopirox is used in lacquers for topical treatment of onychomycosis (fungal infections of the nails). A meta-analysis of the six trials of nail infections available in 2009 concluded that they provided evidence that topical ciclopirox had poor cure rates, and that amorolfine might be substantially more effective, but more research was required.
[1] [2] It is a combination of clotrimazole and betamethasone dipropionate. [1] It is applied to the skin. [1] Common side effects include paresthesia, rash, edema, and secondary infections. [1] In 2022, it was the 242nd most commonly prescribed medication in the United States, with more than 1 million prescriptions. [3] [4]
[5] [3] [1] [2] [8] Topical gels are more stable than creams and ointments, and can adhere well to the site of application. [5] [2] They form an occlusive layer on the application site that can act as a form of protection. [5] They can be washed off easily and are nontoxic due to their unique composition and structure.
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