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  2. Des-gamma carboxyprothrombin - Wikipedia

    en.wikipedia.org/wiki/Des-gamma_carboxyprothrombin

    Des-gamma carboxyprothrombin (DCP), also known as protein induced by vitamin K absence/antagonist-II (PIVKA-II), is an abnormal form of the coagulation protein, prothrombin. Normally, the prothrombin precursor undergoes post-translational carboxylation (addition of a carboxylic acid group) by gamma-glutamyl carboxylase in the liver prior to ...

  3. Lower gastrointestinal bleeding - Wikipedia

    en.wikipedia.org/wiki/Lower_gastrointestinal...

    Vitamin K should be taken orally unless the patient has cirrhosis or biliary obstruction, in which case it should be administered subcutaneously. The full effect of vitamin K is not obtained for 12–24 hours, unlike fresh frozen plasma which immediately reverses clotting abnormalities. The intravenous formulation of vitamin K reverses ...

  4. Gastrointestinal bleeding - Wikipedia

    en.wikipedia.org/wiki/Gastrointestinal_bleeding

    [1] [9] Sometimes in those with small amounts of bleeding no symptoms may be present. [1] Bleeding is typically divided into two main types: upper gastrointestinal bleeding and lower gastrointestinal bleeding. [2] Causes of upper GI bleeds include: peptic ulcer disease, esophageal varices due to liver cirrhosis and cancer, among others. [3]

  5. Vitamin K deficiency - Wikipedia

    en.wikipedia.org/wiki/Vitamin_K_deficiency

    Symptoms include bruising, [2] petechiae, [2] [3] and hematomas. Vitamin K is changed to its active form in the liver by the enzyme Vitamin K epoxide reductase. Activated vitamin K is then used to gamma carboxylate (and thus activate) certain enzymes involved in coagulation: Factors II, VII, IX, X, and protein C and protein S. The inability to ...

  6. 9 silent signs of a vitamin K deficiency - AOL

    www.aol.com/article/lifestyle/2019/08/19/9...

    Get your fill of vitamin K by whipping up a vanilla smoothie, a healthy broccoli slaw salad, or liver and onions. Vitamin K is a fat-soluble vitamin, so you’ll best absorb it in a fat-containing ...

  7. Chronic liver disease - Wikipedia

    en.wikipedia.org/wiki/Chronic_liver_disease

    The treatment of chronic liver disease depends on the cause. Specific conditions may be treated with medications including corticosteroids, interferon, antivirals, bile acids or other drugs. Supportive therapy for complications of cirrhosis include diuretics, albumin, vitamin K, blood products, antibiotics and nutritional

  8. Primary sclerosing cholangitis - Wikipedia

    en.wikipedia.org/wiki/Primary_sclerosing_cholangitis

    These therapies are aimed at relieving symptoms such as itching with antipruritics (e.g. bile acid sequestrants such as cholestyramine); antibiotics to treat episodes of ascending cholangitis; and vitamin supplements, as people with PSC are often deficient in fat-soluble vitamins (A, D, E, and K). [30]

  9. Hypoprothrombinemia - Wikipedia

    en.wikipedia.org/wiki/Hypoprothrombinemia

    A vitamin K-dependent clotting factor is seldom seen as a contributor to inherited prothrombin deficiencies, but lack of Vitamin K decreases the synthesis of prothrombin in liver cells. [ 5 ] Acquired underlying causes of this condition include severe liver disease, warfarin overdose, platelet disorders, and disseminated intravascular ...

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