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Most people know that GLP-1 receptor agonist medications like Ozempic and Wegovy can cause relatively minor side effects like nausea and diarrhea. But new research confirms that more serious ...
A glycine reuptake inhibitor (GRI) is a type of drug which inhibits the reuptake of the neurotransmitter glycine by blocking one or more of the glycine transporters (GlyTs). ). Examples of GRIs include bitopertin (RG1678), iclepertin (BI-425809), ORG-24598, ORG-25935, ALX-5407, and sarcosine, which are selective GlyT1 blockers, and ORG-25435 and N-arachidonylglycine, which are selective GlyT2 blo
In cancer treatment, growth factor receptor inhibitors have been used to target cancer cells. [2]In cancer research, growth factor receptor inhibitors have been applied to protect normal cells selectively from the toxic side-effects of chemotherapy targeted against cancer cells.
Antiglucocorticoid drugs are a class of medications that act to reduce the effects of glucocorticoids, primarily cortisol, in the body. [1] They include direct glucocorticoid receptor antagonists such as mifepristone and synthesis inhibitors such as metyrapone, ketoconazole, and aminoglutethimide. They are used to treat Cushing's syndrome. [2]
The cardioprotective effects of SGLT2 inhibitors have been attributed to the elevated ketone levels. [59] Gliflozins have been posited to exhibit protective effects on the heart, liver, kidneys, anti‐hyperlipidemic, anti‐atherosclerotic, anti‐obesity, anti‐neoplastic effects in in vitro, pre‐clinical, and
As with all hormonal therapies, GnRH antagonists are commonly associated with hormonal side effects such as hot flushes, headache, nausea and weight gain. [18] [19] [20] When used in fertility treatment they can also be associated with abdominal pain and ovarian hyperstimulation.
However, it does act as a high affinity antagonist of the histamine H 1 receptor [24] and is a low to moderate affinity antagonist of the dopamine D 2, serotonin 5-HT 2, and α 1-adrenergic receptors. [3] [23] H 1 receptor antagonism accounts for its antihistamine effects and associated sedative side effects.
Bronchospasms and hypoglycemia occur because at high doses, the drug can be an antagonist for β 2 adrenergic receptors located in the lungs and liver. Bronchospasm occurs due to the blockage of β 2 receptors in the lungs. Hypoglycemia occurs due to decreased stimulation of glycogenolysis and gluconeogenesis in the liver via β 2 receptors ...