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The Human Proteome Project [1] (HPP) is a collaborative effort coordinated by the Human Proteome Organization. [2] Its stated goal is to experimentally observe all of the proteins produced by the sequences translated from the human genome .
Robotic preparation of MALDI mass spectrometry samples on a sample carrier. Proteomics is the large-scale study of proteins. [1] [2] Proteins are vital macromolecules of all living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replication of DNA.
The research underpinning the start of the exploration of the whole human proteome in the Human Protein Atlas program was carried out in the late 1990s and early 2000s. A pilot study employing an affinity proteomics strategy using affinity-purified antibodies raised against recombinant human protein fragments was carried out for a chromosome ...
The Journal of Proteome Research is a peer-reviewed scientific journal published since 2002 by the American Chemical Society. [1] Its publication frequency switched from bimonthly to monthly in 2006. The current editor-in-chief is John R. Yates .
General schema showing the relationships of the genome, transcriptome, proteome, and metabolome (lipidome, glycome). The metabolome refers to the complete set of small-molecule chemicals found within a biological sample. [1] The biological sample can be a cell, a cellular organelle, an organ, a tissue, a tissue extract, a biofluid or an entire ...
CITE-Seq (Cellular Indexing of Transcriptomes and Epitopes by Sequencing) is a method for performing RNA sequencing along with gaining quantitative and qualitative information on surface proteins with available antibodies on a single cell level. [1] So far, the method has been demonstrated to work with only a few proteins per cell.
The Journal of Proteomics is a peer-reviewed scientific journal published by Elsevier.It is the official journal of the European Proteomics Association and the editor-in-chief is Juan Calvete. [1]
A recent resource paper (November 2014) [17] attempts to provide a more comprehensive proteome level map of the human interactome. It found vast uncharted territory in the human interactome, and used diverse methods to build a new interactome map correcting for curation bias, including probing all pairwise combinations of 13 000 protein ...