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Ranitidine, previously sold under the brand name Zantac [a] among others, is a medication used to decrease stomach acid production. [12] It was commonly used in treatment of peptic ulcer disease , gastroesophageal reflux disease , and Zollinger–Ellison syndrome . [ 12 ]
Zantac was first marketed in 1981, [7] and it was described in 1989 as "one of the most expensive drugs on the market", [8] and "the world's biggest-selling prescription drug". [9] Addiction to taking it ("a habit") was how some of its users described Zantac. [ 10 ]
By 1990, generic drug manufacturers such as Apotex and Novopharm were able to acquire ranitidine on the open market at prices significantly less than Glaxo Canada was paying under its 1983 agreement. [9] The Minister of National Revenue subsequently reassessed Glaxo Canada's 1990–1993 taxation years under:
First approved in 1983, Zantac became the world's best- selling medicine in 1988 and one of the first-ever drugs to top $1 billion in annual sales. Originally marketed by a forerunner of GSK, it ...
The trial was due to start on July 24, and would have been the first test of how Zantac cancer claims would fare before a jury. GSK soothes investors by settling first Zantac cancer lawsuit due ...
Sanofi discontinued the ranitidine formulation of Zantac, and the new formulation, Zantac 360, is made with a different active ingredient.
In British Columbia, Canada the cost of the PPIs varies significantly from CA$0.13 to CA$2.38 per dose [91] while all agents in the class appear more or less equally effective. [ 1 ] [ 89 ] Regulatory approval
Ranitidine bismuth citrate 400 mg 2 times a day, metronidazole 500 mg 3 times a day, tetracycline 500 mg 4 times a day. Scheme 4. 2 times a day - ranitidine bismuth citrate 400 mg, tinidazole 500 mg, amoxicillin 1 g. Within 14 days - 2 drugs: Scheme 5. Ranitidine bismuth citrate 400 mg 2 times a day and clarithromycin 500 mg 2 or 3 times a day.
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