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A conjugate vaccine is a type of subunit vaccine which combines a weak antigen with a strong antigen as a carrier so that the immune system has a stronger response to the weak antigen. Vaccines are used to prevent diseases by invoking an immune response to an antigen, part of a bacterium or virus that the immune system recognizes. [ 2 ]
Pharmaceutical compound Sinopharm CNBG COVID-19 vaccine Vaccine description Target SARS-CoV-2 Vaccine type Protein subunit Clinical data Routes of administration Intramuscular Legal status Legal status Full list of Sinopharm NVSI authorizations Identifiers CAS Number 2503126-65-4 Part of a series on the COVID-19 pandemic Scientifically accurate atomic model of the external structure of SARS ...
The Medicago method to manufacture CoVLP was a "molecular farming" technology regarded as rapid, low-cost, and safe. [8] [11] It was proposed specifically for production of COVID-19 vaccines. [12] [13] In February 2022, Health Canada authorized use of CoVLP for preventing COVID-19 infection in adults 18 to 64 years old. [3]
Vaccine Excipients Adenovirus vaccine: This list refers to the type 4 and type 7 adenovirus vaccine tablets licensed in the US: Acetone, alcohol, anhydrous lactose, castor oil, cellulose acetate phthalate, dextrose, D-fructose, D-mannose, FD&C Yellow #6 aluminium lake dye, fetal bovine serum, human serum albumin, magnesium stearate, micro crystalline cellulose, plasdone C, Polacrilin potassium ...
SCB-2019 is a protein subunit COVID-19 vaccine developed by Clover Biopharmaceuticals using an adjuvant from Dynavax technologies. [2] Positive results of Phase I trials for the vaccine were published in The Lancet [3] and the vaccine completed enrollment of 29,000 participants in Phase II/III trials in July 2021. [4]
In April, Ad5-nCoV became the first COVID-19 vaccine candidate in the world to begin Phase II trials. [30] The Phase II trial results were published in the peer-reviewed journal The Lancet in August 2020, and noted neutralizing antibody and T cell responses based on statistical analyses of data involving 508 eligible participants. [31]
In the European Union, the combination is indicated for the treatment of COVID‑19 in people aged twelve years of age and older weighing at least 40 kilograms (88 lb) who do not require supplemental oxygen and who are at high increased risk of progressing to severe COVID‑19; [10] and for the prevention of COVID‑19 in people aged twelve years of age and older weighing at least 40 kilograms ...
The vaccine consists of a version of the receptor binding domain (RBD) of the SARS‑CoV‑2 spike protein, together with the adjuvants aluminium hydroxide gel and CpG 1018. [2] As the RBD protein is poorly immunogenic alone, adjuvantation is essential for a RBD-based vaccine immunogenicity. [ 9 ]