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Dantrolene sodium, sold under the brand name Dantrium among others, is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. [ 5 ] [ 6 ] [ 7 ] It achieves this by inhibiting Ca 2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors . [ 8 ]
Baclofen, diazepam and dantrolene remain the three most commonly used pharmacologic agents in the treatment of spastic hypertonia. Baclofen is generally the drug of choice for spinal cord types of spasticity, while sodium dantrolene is the only agent which acts directly on muscle tissue. Tizanidine is also available.
A physiotherapist can help to reduce spasticity and avoid the development of contractures with techniques such as passive stretching. [125] There is evidence, albeit limited, of the clinical effectiveness of THC and CBD extracts, [126] baclofen, [127] dantrolene, [128] diazepam, [129] and tizanidine.
Dantrolene remains the only drug known to be effective in the treatment of MH. [30] The recommended dose of dantrolene is 2.5 mg/kg, repeated as necessary. [5] It is recommended that each hospital keeps a minimum stock of 36 dantrolene vials (720 mg), sufficient for four doses in a 70-kg person. [36]
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A general treatment guideline can be followed that involves: [23] The initial focus on first activating contraction of antagonist muscles to provide reciprocal inhibition and lengthen spastic muscles; Reciprocal actions are attempted. Agonist contractions are performed first in small ranges progressing to larger arcs of movement
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related to: dantrolene for spasticity in adults treatment guidelines