Search results
Results from the WOW.Com Content Network
Buruli ulcer has been the subject of scientific research since the description of M. ulcerans in 1948, and the demonstration that the bacteria could cause ulcers in laboratory animals. [ 11 ] [ 54 ] While several animals are susceptible to M. ulcerans ulcers, mice (particularly BALB/c and C57BL/6 mice) are most commonly used to model Buruli ...
A 2004 WHO resolution "called for increasing surveillance and control, and for intensified research to develop tools to diagnose, treat and prevent" Buruli ulcer. [4] In 2009, a strategy to promote early detection and provide wider access to antibiotics was adopted. [6]
The bacteria can infect humans and some other animals, causing persistent open wounds called Buruli ulcer. M. ulcerans is closely related to Mycobacterium marinum, from which it evolved around one million years ago, and more distantly to the mycobacteria which cause tuberculosis and leprosy.
Deep ulcers can cause scarring of muscles and tendons, resulting in permanent disability. Buruli ulcer is caused by skin infection with bacteria called Mycobacterium ulcerans . The mechanism by which M. ulcerans is transmitted from the environment to humans is not known, but may involve the bite of an aquatic insect or the infection of open wounds.
Mycolactone is a polyketide-derived macrolide produced and secreted by a group of very closely related pathogenic mycobacteria species including M. ulcerans, M. liflandii (an unofficial designation), M. pseudoshottsii, and some strains of M. marinum.
The two main types of human skin are: glabrous skin, the hairless skin on the palms and soles (also referred to as the "palmoplantar" surfaces), and hair-bearing skin. [3] Within the latter type, the hairs occur in structures called pilosebaceous units , each with hair follicle , sebaceous gland , and associated arrector pili muscle. [ 4 ]
Tropical ulcer, more commonly known as jungle rot, is a chronic ulcerative skin lesion thought to be caused by polymicrobial infection with a variety of microorganisms, including mycobacteria. It is common in tropical climates .
English: From source: "Characteristic histopathological features of tissue samples taken before start of antibiotic treatment. Histological sections were stained either with Haematoxylin-Eosin (HE) (A, C–E), Ziehl-Neelsen (counterstain methylenblue) (ZN) (B) ..