Search results
Results from the WOW.Com Content Network
Quiescent stellate cells represent 5-8% of the total number of liver cells. [4] Each cell has several long cytoplasmic protrusions that extend from the cell body and wrap around the sinusoids. [5] The lipid droplets in the cell body store vitamin A as retinyl palmitate. [6] Hepatic stellate cells store 50–80% of the body's vitamin A. [6]
The Kupffer cells can take up and destroy foreign material such as bacteria. Hepatocytes are separated from the sinusoids by the space of Disse. Hepatic stellate cells are present in the space of Disse and are involved in scar formation in response to liver damage. Defenestration happens when LSECs are lost rendering the sinusoid as an ordinary ...
When a cell undergoes asymmetric division, it produces one stem and one differentiated cell. Production of new stem cells is necessary to maintain this population within the body. [7] Like all cells, hematopoietic stem cells undergo metabolic shifts to meet their bioenergetic needs throughout development. [1]
Liver injury from a number of causes can activate the hepatic stellate cells into transdifferentiated and prolific myofibroblasts. [4] The myofibroblasts synthesize and secrete components of the extracellular matrix including collagen into the perisinusoidal space. [ 4 ]
Fatty liver disease (FLD), also known as hepatic steatosis and steatotic liver disease (SLD), is a condition where excess fat builds up in the liver. [1] Often there are no or few symptoms. [ 1 ] [ 2 ] Occasionally there may be tiredness or pain in the upper right side of the abdomen . [ 1 ]
The cells were first observed by Karl Wilhelm von Kupffer in 1876. [11] The scientist called them "Sternzellen" (star cells or hepatic stellate cell) but thought, inaccurately, that they were an integral part of the endothelium of the liver blood vessels and that they originated from it.
The main liver cells are called hepatocytes; however, there are other cells that can be observed in a liver sample such as Kupffer cells (macrophages). [2] The liver is the biggest gland of the body. It has a wide variety of functions that range from the destruction of old blood cells to the control of the whole metabolism of macromolecules . [ 3 ]
ER stress is known to activate hepatic de novo lipogenesis, inhibit VLDL secretion, promote insulin resistance and inflammatory process, and promote cell apoptosis. Thus it increase the level of fat accumulation and worsens the NAFLD to a more serious hepatic state. [ 29 ]