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Leishmaniasis is a wide array of clinical manifestations caused by protozoal parasites of the Trypanosomatida genus Leishmania. [7] It is generally spread through the bite of phlebotomine sandflies , Phlebotomus and Lutzomyia , and occurs most frequently in the tropics and sub-tropics of Africa, Asia, the Americas, and southern Europe.
Leishmania / l iː ʃ ˈ m eɪ n i ə,-ˈ m æ n-/ [1] is a parasitic protozoan, a single-celled organism of the genus Leishmania that is responsible for the disease leishmaniasis. [2] [3] [4] They are spread by sandflies of the genus Phlebotomus in the Old World, and of the genus Lutzomyia in the New World.
Leishmania infantum is the causative agent of infantile visceral leishmaniasis in the Mediterranean region [1] and in Latin America, where it has been called Leishmania chagasi. [ 2 ] [ 3 ] It is also an unusual cause of cutaneous leishmaniasis , [ 4 ] which is normally caused by specific lineages (or zymodemes).
Cutaneous leishmaniasis is commonly characterized with skin lesions, which can appear localized, or throughout the body. While mucocutaneous leishmaniasis is characterized with ulcers around the skin, mouth, and nose. This form of Leishmaniasis has also been known to can spread by metastasis and can be deadly. [2]
When it infects children, grayscale generally leaves children malformed and disabled but alive. However, in A Dance with Dragons, it is revealed to be generally fatal to adults. The disease is contracted by touch and slowly turns the skin (small patches in children and the entire body in adults) of the victim to into a gray, stone-like form.
Leishmania major is a species of parasite found in the genus Leishmania, and is associated with the disease zoonotic cutaneous leishmaniasis (also known as Aleppo boil, Baghdad boil, Bay sore, Biskra button, Chiclero ulcer, Delhi boil, Kandahar sore, Lahore sore, Oriental sore, Pian bois, and Uta). [1]
Leishmaniavirus (also known as Leishmania RNA virus or LRV) is a genus of double-stranded RNA virus, in the family Totiviridae.Protozoa serve as natural hosts, and Leishmaniaviruses are present in several species of the human protozoan parasite Leishmania.
L. tropica causes a broad spectrum of leishmaniasis forms in humans. Most common is a variant called dry-type cutaneous leishmaniasis. After an incubation period lasting more than 2 months, a small brownish nodular lesion will appear with a slowly extending plaque reaching a size of 1–2 centimetres (0.39–0.79 in) after 6 months.