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Benznidazole is a nitroimidazole antiparasitic with good activity against acute infection with Trypanosoma cruzi, commonly referred to as Chagas disease. [14] Like other nitroimidazoles, benznidazole's main mechanism of action is to generate radical species which can damage the parasite's DNA or cellular machinery . [ 17 ]
In Chagas disease it is a second-line option to benznidazole. [5] It is given by mouth. [2] Common side effects include abdominal pain, headache, nausea, and weight loss. [2] There are concerns from animal studies that it may increase the risk of cancer but these concerns have not been found in human trials. [5]
The logo of the Drugs for Neglected Diseases initiative (DNDi) The Drugs for Neglected Diseases initiative (DNDi) is a collaborative, patients' needs-driven, non-profit drug research and development (R&D) organization that is developing new treatments for neglected diseases, notably leishmaniasis, sleeping sickness (human African trypanosomiasis, HAT), Chagas disease, [1] malaria, filarial ...
Two widely touted Alzheimer’s drugs have been shown to enable patients to remain in their homes for longer periods of time. Those medications, however, are not without their risks and side effects.
Image credits: viralsumo1 #6. 1. Gentle Admittedly men are quite strong and can sometimes come off as a bull in a China shop. When a man is considerate and gentle, it genuinely makes my heart melt.
UG Solutions - a low-profile company founded in 2023 and based in Davidson, North Carolina - is offering a daily rate starting at $1,100 with a $10,000 adv Gaza checkpoint to be staffed by scores ...
The probability of success (POS) is a statistics concept commonly used in the pharmaceutical industry including by health authorities to support decision making. The probability of success is a concept closely related to conditional power and predictive power .
A 2022 study analyzed hormones among nearly 8,000 men aged 20–70 found that bioavailable testosterone levels peaked ... and are shown to be highly effective, with an overall success rate of up ...