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Downstream processing and analytical bioseparation both refer to the separation or purification of biological products, but at different scales of operation and for different purposes. Downstream processing implies manufacture of a purified product fit for a specific use, generally in marketable quantities, while analytical bioseparation refers ...
Downstream, in manufacturing, refers to processes which occur later on in a production sequence or production line. [1] Viewing a company "from order to cash" might have high-level processes such as marketing, sales, order entry, manufacturing, packaging, shipping, and invoicing. Each of these could be deconstructed into many sub-processes and ...
A bioprocess is composed mainly of three stages—upstream processing, bioreaction, and downstream processing—to convert raw material to finished product. [11] The raw material can be of biological or non-biological origin. It is first converted to a more suitable form for processing.
Protein precipitation is widely used in downstream processing of biological products in order to concentrate proteins and purify them from various contaminants. For example, in the biotechnology industry protein precipitation is used to eliminate contaminants commonly contained in blood. [1]
Therapeutic cell manufacturing processes can be separated into upstream processes and downstream processes. The upstream process is defined as the entire process from early cell isolation and cultivation, to cell banking and culture expansion of the cells until final harvest (termination of the culture and collection of the live cell batch).
Downstream may refer to: Downstream (hydrology) , the direction towards the mouth of a stream, i.e. the direction the current flows Downstream (bioprocess) , when a cell mass from an upstream process (isolated, grown and harvested) is further processed to meet purity and quality requirements
"Lenticel breakdown" is a global skin disorder of apples in which lenticels develop dark 1–8 mm diameter pits shortly after processing and packing. [ 18 ] [ 19 ] It is most common on the ' Gala ' ( Malus × domestica ) variety, particularly the ' Royal Gala ', and also occurs in ' Fuji ', ' Granny Smith ', ' Golden Delicious ', and 'Delicious ...
The oil and gas industry is usually divided into three major sectors: upstream, midstream, and downstream. The downstream sector is the refining of petroleum crude oil and the processing and purifying of raw natural gas , [ 1 ] as well as the marketing and distribution of products derived from crude oil and natural gas .