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Ticagrelor, sold under the brand name Brilinta among others, is a medication used for the prevention of stroke, heart attack and other events in people with acute coronary syndrome, meaning problems with blood supply in the coronary arteries. It acts as a platelet aggregation inhibitor by antagonising the P2Y 12 receptor. [7]
Common side effects include nausea, dry mouth, diarrhea, constipation, vomiting (3-6% of people), and sexual dysfunction. [15] [11] Serious side effects may include suicide in those under the age of 25, serotonin syndrome, bleeding, mania, and SIADH. [15] A withdrawal syndrome may occur if the medication is abruptly stopped or the dose is ...
Heartburn is a common symptom of late term pregnancy during which up to 80% of pregnant women have experienced it by the end of their third trimester. [12] Heartburn often indicates the development of gastro-esophageal reflux disease (GERD), where the lower esophageal sphincter relaxes due to elevated progesterone levels causing increased ...
More than a year after AstraZeneca (AZN) filed for approval of its potential blockbuster heart drug Brilinta, the Food and Drug Administration appears ready to make its decision on Thursday. The ...
Bentracimab is a monoclonal antibody medication which has been shown in phase one and two clinical trials to function as a reversal agent for the anti–blood clotting drug ticagrelor (which acts as a P2Y 12 inhibitor and is sold under the brand name Brilinta among others). [2]
While definitive sites of metabolism have not been firmly established, there are several metabolites worthy of note. N-Desethylbrinzolamide is an active metabolite of the parent compound, and thus exhibits carbonic anhydrase inhibitory activity (largely carbonic anhydrase-I, when in the presence of Brinzolamide) and also accumulates in the erythrocytes.
Health experts answer four of the most frequently asked questions about the effects weight loss drugs like Ozempic and Wegovy can have on fertility and pregnancy. Here's what to know.
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.