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  2. Amyloid beta - Wikipedia

    en.wikipedia.org/wiki/Amyloid_beta

    By NMR-guided simulations, amyloid beta 1-40 and amyloid beta 1-42 also seem to feature highly different conformational states, [59] with the C-terminus of amyloid beta 1-42 being more structured than that of the 1-40 fragment. Low-temperature and low-salt conditions allowed to isolate pentameric disc-shaped oligomers devoid of beta structure. [60]

  3. Anti-amyloid drugs - Wikipedia

    en.wikipedia.org/wiki/Anti-amyloid_drugs

    Aducanumab, sold under the brand name Aduhelm, is a monoclonal antibody designed to treat Alzheimer's disease. It is a monoclonal antibody that targets aggregated forms (plaque) of amyloid beta (Aβ) found in the brains of people with Alzheimer's disease to reduce its buildup. [10] It was developed by Biogen and Eisai. [11] Aducanumab is given via intravenous infusion. [5] Aducanumab was ...

  4. Biomarkers of Alzheimer's disease - Wikipedia

    en.wikipedia.org/wiki/Biomarkers_of_Alzheimer's...

    Amyloid beta (Aβ) is composed of a family of peptides produced by proteolytic cleavage of the type I transmembrane spanning glycoprotein amyloid-beta precursor protein (APP). Amyloid plaque Aβ protein species ends in residue 40 or 42, [ 4 ] but it is suspected that Aβ42 form is crucial in the pathogenesis of AD.

  5. Solanezumab - Wikipedia

    en.wikipedia.org/wiki/Solanezumab

    Solanezumab is thought to act as an “amyloid beta sink” [14] that is “facilitating flux of amyloid beta from a central to peripheral compartment”. [14] This increases the peripheral elimination of both amyloid beta and the antibody. Amyloid beta plaques mostly consist of amyloid beta42.

  6. Amyloid - Wikipedia

    en.wikipedia.org/wiki/Amyloid

    Modern antibody technology and immunohistochemistry has made specific staining easier, but often this can cause trouble because epitopes can be concealed in the amyloid fold; in general, an amyloid protein structure is a different conformation from the one that the antibody recognizes.

  7. Aducanumab - Wikipedia

    en.wikipedia.org/wiki/Aducanumab

    Aducanumab, sold under the brand name Aduhelm, is a monoclonal antibody designed to treat Alzheimer's disease. [2] [3] It is a monoclonal antibody [3] [2] that targets aggregated forms (plaque) [4] [5] of amyloid beta (Aβ) found in the brains of people with Alzheimer's disease to reduce its buildup. [6] [7] It was developed by Biogen and Eisai ...

  8. P3 peptide - Wikipedia

    en.wikipedia.org/wiki/P3_peptide

    p3 peptide also known as amyloid β- peptide (Aβ) 17–40/42 is the peptide resulting from the α-and γ-secretase cleavage from the amyloid precursor protein . It is known to be the major constituent of diffuse plaques observed in Alzheimer's disease (AD) brains and pre-amyloid plaques in people affected by Down syndrome. However, p3 peptide ...

  9. Crenezumab - Wikipedia

    en.wikipedia.org/wiki/Crenezumab

    Crenezumab is a fully humanized monoclonal antibody against human 1-40 and 1-42 beta amyloid, which is being investigated as a treatment of Alzheimer's disease. [1] Crenezumab is highly homologous to solanezumab, another monoclonal antibody targeting amyloid-β peptides. [2]

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