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Opiate overdose symptoms and signs can be referred to as the "opioid toxidrome triad": decreased level of consciousness, pinpoint pupils and respiratory depression. Other symptoms include seizures and muscle spasms. Sometimes an opiate overdose can lead to such a decreased level of consciousness such that the person will not wake up.
[56] [78] As a result of downregulated signaling through these proteins, opiates cause VTA neuronal hyperexcitability and shrinkage (specifically, the size of the neuronal soma is reduced). [56] It has been shown that when an opiate-naive person begins using opiates in concentrations that induce euphoria, BDNF signaling increases in the VTA. [79]
A toxidrome (a portmanteau of toxic and syndrome, coined in 1970 by Mofenson and Greensher [2]) is a syndrome caused by a dangerous level of toxins in the body. It is often the consequence of a drug overdose. Common symptoms include dizziness, disorientation, nausea, vomiting and oscillopsia.
Many classical opiates are also referred to as opioids in modern nomenclature. Opioids include opiates, an older term that refers to such drugs derived from opium, including morphine itself. [24] Opiate is properly limited to the natural alkaloids found in the resin of the opium poppy although some include semi-synthetic derivatives.
“The brain may get OK with time in some persons. But it’s hard to find a person who has completely normal brain function after a long cycle of opiate addiction, not without specific medication treatment.” An abstinence-only treatment that may have a higher success rate for alcoholics simply fails opiate addicts.
An opiate is an alkaloid substance derived from opium (or poppy straw). [1]
Suboxone tablet (Buprenorphine/naloxone) delivers the opioid drug through a sublingual route, giving fast onset of effects.. Opioid withdrawal is a set of symptoms (a syndrome) arising from the sudden cessation or reduction of opioids where previous usage has been heavy and prolonged.
Watch firsthand, in 360 video, as Susan Sarandon listens and learns about refugees' hopes, dreams and journeys