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Top: An ancestral gene duplicates to produce two paralogs (Genes A and B). A speciation event produces orthologs in the two daughter species. Bottom: in a separate species, an unrelated gene has a similar function (Gene C) but has a separate evolutionary origin and so is an analog.
The term "ortholog" was coined in 1970 by the molecular evolutionist Walter Fitch. [41] Homologous sequences are paralogous if they were created by a duplication event within the genome. For gene duplication events, if a gene in an organism is duplicated, the two copies are paralogous. They can shape the structure of whole genomes and thus ...
Orthology (biology) - homologous sequences originate from the same ancestors (homolog e.g. all globin protein), which are separated from each other after a speciation event, e.g. human beta and chimp beta globin. An orthologous gene is a gene in different species that evolved from a common ancestor by speciation.
Some basic conventions, such as (1) that animal/human homolog (ortholog) pairs differ in letter case (title case and all caps, respectively) and (2) that the symbol is italicized when referring to the gene but nonitalic when referring to the protein, are often not followed by contributors to medical journals.
Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. [5]
Synteny (in the modern sense) between human and mouse chromosomes. Colors in the human chromosomes indicate regions homologous with parts of the mouse chromosome of the same color.
The eggNOG database is a database of biological information hosted by the EMBL.It is based on the original idea of COGs (clusters of orthologous groups) [2] [3] and expands that idea to non-supervised orthologous groups constructed from numerous organisms. [4]
In biological research, experiments or tests are often used to study predicted causal relationships between two phenomena. [1] These causal relationships may be described in terms of the logical concepts of necessity and sufficiency. Consider the statement that a phenomenon x causes a phenomenon y.