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The distribution and severity of TDP-43 inclusions, especially in the amygdala and hippocampus (but with none or modest density of pathology in the frontal cortex), confirm the presence of LATE. The specific severity/extent of LATE-NC follows on the basic staging scheme based on a stereotypic expansion of TDP-43 pathology in the aged brain. [1]
Following a frontal lobe injury, an individual's abilities to make good choices and recognize consequences are often impaired. Memory impairment is another common effect associated with frontal lobe injuries, but this effect is less documented and may or may not be the result of flawed testing. [ 3 ]
The left inferior frontal junction and left anterior cuneus/precuneus were the only regions in a larger set of regions associated with executive functions, that consistently showed age differences in brain activity. [59]
Frontal lobe disorder, also frontal lobe syndrome, is an impairment of the frontal lobe of the brain due to disease or frontal lobe injury. [5] The frontal lobe plays a key role in executive functions such as motivation, planning, social behaviour, and speech production. Frontal lobe syndrome can be caused by a range of conditions including ...
FCMS is primarily originates from damages in the posterior region of the inferior frontal gyrus and inferior region of the precentral gyrus. [6] Anatomically, the word operculum is defined as the cortices encompassing the insula , which includes the pre and post-central, inferior-frontal, supramarginal, angular inferior parietal, and superior ...
Orbital part of inferior frontal gyrus (pars orbitalis) (cortex inferior and anterior to the horizontal ramus of the lateral sulcus) Cytoarchitecturally the opercular part of the inferior frontal gyrus is known as Brodmann area 44 (BA44). The triangular part of the inferior frontal gyrus is known as Brodmann area 45 (BA45), and the orbital part ...
The uncinate fasciculus is a hook-shaped bundle of axons that links anterior portions of the temporal lobe with the inferior frontal gyrus and the lower surfaces of the frontal lobe. It arises in the anterior temporal lobe and amygdala , in the temporal lobe curving in an upward pathway behind the external capsule inward of the insular cortex ...
The anterior superior frontal lobe is known as the prefrontal cortex which is responsible for the initiation and ideation of verbal speech. [7] The damage leaves the major language networks, Broca's and Wernicke’s areas and the arcuate fasiculus, unaffected. [1]