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Abrupt withdrawal may cause delirium, seizures, or other adverse effects, especially if used for prolonged periods and at high doses. [ 45 ] [ 46 ] When drug tolerance and physical dependence to zolpidem develop, treatment usually entails a gradual dose reduction over a period of months to minimize withdrawal symptoms , which can resemble those ...
Zaleplon, sold under the brand name Sonata among others, is a sedative and hypnotic which is used to treat insomnia. It is a nonbenzodiazepine or Z-drug of the pyrazolopyrimidine class. [ 10 ] It was developed by King Pharmaceuticals and approved for medical use in the United States in 1999.
Zaleplon or other nonimpairing sleep aids were recommended be used instead of zopiclone to reduce traffic accidents. [87] Zopiclone, as with other hypnotic drugs, is sometimes used to carry out criminal acts such as sexual assaults. [88] Zopiclone has crosstolerance with barbiturates and is able to suppress barbiturate withdrawal symptoms.
A systematic review and meta-analysis has demonstrated that approximately 15% of individuals experience withdrawal symptoms, such as dizziness, headache, nausea, insomnia and irritability, when ...
Chemical structure of the prototypical Z-drug zolpidem. Nonbenzodiazepines (/ ˌ n ɒ n ˌ b ɛ n z oʊ d aɪ ˈ æ z ɪ p iː n,-ˈ eɪ-/ [1] [2]), sometimes referred to colloquially as Z-drugs (as many of their names begin with the letter "z"), are a class of psychoactive, depressant, sedative, hypnotic, anxiolytic drugs that are benzodiazepine-like in uses, such as for treating insomnia [3 ...
Zaleplon (Sonata) Zolpidem ... Dependent users may get withdrawal symptoms ranging from restlessness and insomnia to convulsions and death. When users become ...
In 2015, the American Geriatrics Society reviewed the safety information about eszopiclone and similar drugs and concluded that the "nonbenzodiazepine, benzodiazepine receptor agonist hypnotics (eszopiclone, zaleplon, zolpidem) are to be avoided without consideration of duration of use because of their association with harms balanced with their ...
As with all GABAA receptor agonists, Placidyl can be habit forming and extremely physically addictive (with potentially lethal withdrawal resembling delirium tremens and benzodiazepine withdrawal). After prolonged use, withdrawal symptoms may include convulsions, hallucinations, and amnesia. As with most hypnotics, Placidyl was indicated for ...
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