Search results
Results from the WOW.Com Content Network
Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by the CHEK1 gene. [ 5 ] [ 6 ] Chk1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response. [ 7 ]
The human genome contains about 500 protein kinase genes and they constitute about 2% of all human genes. [1] There are two main types of protein kinase. The great majority are serine/threonine kinases, which phosphorylate the hydroxyl groups of serines and threonines in their targets.
The protein kinase domain is a structurally conserved protein domain containing the catalytic function of protein kinases. [2] [3] [4] Protein kinases are a group of enzymes that move a phosphate group onto proteins, in a process called phosphorylation. This functions as an on/off switch for many cellular processes, including metabolism ...
Dihydroxyacetone kinase in complex with a non-hydrolyzable ATP analog (AMP-PNP). Coordinates from PDB ID:1UN9. [1]In biochemistry, a kinase (/ ˈ k aɪ n eɪ s, ˈ k ɪ n eɪ s,-eɪ z /) [2] is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.
Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene. [5] [6] [7] [8]
5591 19090 Ensembl ENSG00000253729 ENSMUSG00000022672 UniProt P78527 P97313 RefSeq (mRNA) NM_001081640 NM_006904 NM_011159 RefSeq (protein) NP_001075109 NP_008835 NP_035289 Location (UCSC) Chr 8: 47.77 – 47.96 Mb Chr 16: 15.46 – 15.66 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA-dependent protein kinase catalytic subunit, also known as DNA-PKcs, is an enzyme that plays a ...
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [5]
TRAF2 and NCK-interacting protein kinase is an enzyme that in humans is encoded by the TNIK gene. [5] [6] [7] TNIK is involved in various cellular processes, including signal transduction, gene transcription, and cytoskeletal organization. As an emerging area of therapeutic research, TNIK inhibitors have shown potential in addressing a range of ...