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  2. Spironolactone - Wikipedia

    en.wikipedia.org/wiki/Spironolactone

    [24] [unreliable source?] [25] [26] [unreliable medical source?] [4] [27] Spironolactone belongs to a class of medications known as potassium-sparing diuretics. [4] Spironolactone was discovered in 1957, and was introduced in 1959. [28] [29] [30] It is on the World Health Organization's List of Essential Medicines. [31] It is available as a ...

  3. Mineralocorticoid receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/Mineralocorticoid_receptor...

    This group of drugs is often used as adjunctive therapy, in combination with other drugs, for the management of chronic heart failure. Spironolactone, the first member of the class, is also used in the management of hyperaldosteronism (including Conn's syndrome) and female hirsutism (due to additional antiandrogen actions).

  4. Pharmacodynamics of spironolactone - Wikipedia

    en.wikipedia.org/wiki/Pharmacodynamics_of...

    Spironolactone has been identified as an inhibitor of NRG1‐ERBB4 signaling. [142] Spironolactone has been found to act as a potent inhibitor of the pannexin 1 channel, and this action appears to be involved in its antihypertensive effects independently of MR antagonism. [143] Spironolactone has been found to block hERG channels. [144]

  5. Category:Spironolactone - Wikipedia

    en.wikipedia.org/wiki/Category:Spironolactone

    Pages in category "Spironolactone" The following 10 pages are in this category, out of 10 total. This list may not reflect recent changes. ...

  6. Spirolactone - Wikipedia

    en.wikipedia.org/wiki/Spirolactone

    Spirolactones are a class of functional group in organic chemistry featuring a cyclic ester attached spiro to another ring system. The name is also used to refer to a class of synthetic steroids, called steroid-17α-spirolactones, 17α-spirolactosteroids, or simply 17α-spirolactones, which feature their spirolactone group at the C17α position.

  7. 6β-Hydroxy-7α-thiomethylspironolactone - Wikipedia

    en.wikipedia.org/wiki/6β-Hydroxy-7α...

    Spironolactone is a prodrug with a short terminal half-life of 1.4 hours. [5] [6] [7] The active metabolites of spironolactone have extended terminal half-lives of 13.8 hours for 7α-TMS, 15.0 hours for 6β-OH-7α-TMS, and 16.5 hours for canrenone, and accordingly, these metabolites are responsible for the therapeutic effects of the drug. [5] [6

  8. List of cardiac pharmaceutical agents - Wikipedia

    en.wikipedia.org/wiki/List_of_cardiac...

    Class of medications that are competitive antagonists that block the receptor sites for the endogenous catecholamines epinephrine (adrenaline) and norepinephrine (noradrenaline) on adrenergic beta receptors, of the sympathetic nervous system.

  9. 7α-Thiomethylspironolactone - Wikipedia

    en.wikipedia.org/wiki/7α-Thiomethylspironolactone

    Spironolactone is a prodrug with a short terminal half-life of 1.4 hours. [5] [6] [7] The active metabolites of spironolactone have extended terminal half-lives of 13.8 hours for 7α-TMS, 15.0 hours for 6β-OH-7α-TMS, and 16.5 hours for canrenone, and accordingly, these metabolites are responsible for the therapeutic effects of the drug. [5] [6]

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