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  2. Muscle weakness - Wikipedia

    en.wikipedia.org/wiki/Muscle_weakness

    Muscle weakness can also be classified as either "proximal" or "distal" based on the location of the muscles that it affects. Proximal muscle weakness affects muscles closest to the body's midline, while distal muscle weakness affects muscles further out on the limbs. Proximal muscle weakness can be seen in Cushing's syndrome [18] and ...

  3. Anatomical terms of location - Wikipedia

    en.wikipedia.org/wiki/Anatomical_terms_of_location

    Thus the upper arm in humans is proximal and the hand is distal. "Proximal and distal" are frequently used when describing appendages, such as fins, tentacles, and limbs. Although the direction indicated by "proximal" and "distal" is always respectively towards or away from the point of attachment, a given structure can be either proximal or ...

  4. Biceps tendon rupture - Wikipedia

    en.wikipedia.org/wiki/Biceps_tendon_rupture

    Distal tendon rupture will cause significant weakness with respect to forearm supination and flexion, whereas proximal tendon ruptures do not cause significant weakness as a result of their dual proximal tendinous attachments serving as redundancy. [1] [4] This image shows a biceps brachii tendon rupture on the right arm.

  5. Motor neuron diseases - Wikipedia

    en.wikipedia.org/wiki/Motor_neuron_diseases

    Various patterns of muscle weakness occur in different motor neuron diseases. [6] Weakness can be symmetric or asymmetric, and it can occur in body parts that are distal, proximal, or both. According to Statland et al., there are three main weakness patterns that are seen in motor neuron diseases, which are: [6] [9]

  6. Spinal muscular atrophies - Wikipedia

    en.wikipedia.org/wiki/Spinal_muscular_atrophies

    Distal spinal muscular atrophy with calf predominance. Distal hereditary motor neuronopathy type 2D (DHMN2D) 615575: FBXO38: 5q32: Autosomal dominant: Juvenile- or adult-onset, slowly progressive, affects both proximal and distal muscles, initially manifests with calf weakness which progresses to hands Distal spinal muscular atrophy with vocal ...

  7. Polyneuropathy - Wikipedia

    en.wikipedia.org/wiki/Polyneuropathy

    The diagnosis of polyneuropathy begins with a history (anamnesis) and physical examination to ascertain the pattern of the disease process (such as arms, legs, distal, proximal), if they fluctuate, and what deficits and pain are involved. If pain is a factor, determining where and how long it has been present is important; one also needs to ...

  8. Limb–girdle muscular dystrophy - Wikipedia

    en.wikipedia.org/wiki/Limb–girdle_muscular...

    By definition, all limb girdle muscular dystrophies (LGMD) cause progressive proximal weakness, [3] meaning weakness of the muscles on or close to the torso that worsens over time. Explicitly, LGMD preferentially affects muscles of the hip girdle, thigh, shoulder girdle, and/or upper arm. [8] [6] The muscle weakness is generally symmetric. [11]

  9. Distal myopathy - Wikipedia

    en.wikipedia.org/wiki/Distal_myopathy

    Distal myopathy is a group of rare genetic disorders that cause muscle damage and weakness, predominantly in the hands and/or feet. Mutation of many different genes can be causative. Mutation of many different genes can be causative.