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1q21.1 duplication syndrome, also known as 1q21.1 microduplication, is an uncommon copy number variant associated with several congenital abnormalities, including developmental delay, dysmorphic traits, autism spectrum disorder, and congenital cardiac defects. [1]
The Sonic Mania developer Christian Whitehead said that the changes to the Sonic formula "stemmed from a – perhaps misplaced – desire to continue to push Sonic as a AAA brand". [140] Journalists, Whitehead, and the former Sega of America marketing director Al Nilsen criticized the number of characters added to the series, [ 140 ] [ 195 ...