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A depsipeptide is a peptide in which one or more of its amide, -C (O)NHR-, groups are replaced by the corresponding ester, -C (O)OR-. [1] Many depsipeptides have both peptide and ester linkages. [2] Elimination of the N–H group in a peptide structure results in a decrease of H-bonding capability, which is responsible for secondary structure ...
Cyclothymia (/ ˌ s aɪ k l ə ˈ θ aɪ m i ə /, siy-kluh-THIY-mee-uh), also known as cyclothymic disorder, psychothemia / psychothymia, [5] bipolar III, [6] affective personality disorder [7] and cyclothymic personality disorder, [8] is a mental and behavioural disorder [9] that involves numerous periods of symptoms of depression and periods of symptoms of elevated mood. [3]
Pyramidal signs can be a result from different types of damage to the brain or spinal cord, such as strokes, infections, tumors, hemorrhagic events, multiple sclerosis, or trauma. [ 4 ] Parkinsonian-Pyramidal syndrome (PPS) is a combination of both pyramidal and parkinsonian signs that manifest in various neurodegenerative diseases.
Kleine–Levin syndrome (KLS) is a rare neurological disorder characterized by persistent episodic hypersomnia accompanied by cognitive and behavioral changes. These changes may include disinhibition (failure to inhibit actions or words), sometimes manifested through hypersexuality, hyperphagia or emotional lability, and other symptoms, such as derealization.
Premenstrual dysphoric disorder (PMDD) is a mood disorder characterized by emotional, cognitive, and physical symptoms. PMDD causes significant distress or impairment in menstruating women during the luteal phase of the menstrual cycle. The symptoms occur in the luteal phase (between ovulation and menstruation), improve within a few days after ...
Childhood disintegrative disorder (CDD), also known as Heller's syndrome and disintegrative psychosis, is a rare condition characterized by late onset of developmental delays—or severe and sudden reversals—in language (receptive and expressive), social engagement, bowel and bladder, play and motor skills. [3][4] Researchers have not been ...
The AR protein (pictured) mediates the effects of androgens in the human body. Complete androgen insensitivity syndrome (CAIS) is an AIS condition that results in the complete inability of the cell to respond to androgens. [1][2][3] As such, the insensitivity to androgens is only clinically significant when it occurs in individuals who are ...
Familial Mediterranean fever. Familial Mediterranean fever has an autosomal recessive pattern of inheritance. Specialty. Rheumatology, Immunology. Familial Mediterranean fever (FMF) is a hereditary inflammatory disorder. [1]: 149 FMF is an autoinflammatory disease caused by mutations in Mediterranean fever gene, which encodes a 781–amino acid ...