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Cyclic peptides are polypeptide chains with a circular sequence of bonds, often found in nature or synthesized in the laboratory. They have various applications in medicine, such as antibiotics and immunosuppressive agents, and can be classified by the types of bonds that comprise the ring.
Peptides are short chains of amino acids linked by peptide bonds, and can be classified according to their sources and functions. Learn about ribosomal and nonribosomal peptides, peptide synthesis, peptide interactions, and peptide families with hormonal, antimicrobial, and other activities.
This page was last edited on 6 September 2021, at 23:16 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply.
Cyclotides are cyclic cystine knot peptides with diverse biological activities and structural features. They are isolated from various plant families and have a conserved gene structure and biosynthesis pathway.
Cyclic glycine-proline (cGP) is a small neuroactive peptide that belongs to a group of bioactive 2,5-diketopiperazines (2,5-DKPs) and is also known as cyclo-glycine-proline. cGP is a neutral, stable naturally occurring compound and is endogenous to the human body; found in human plasma, breast milk and cerebrospinal fluid.
A number of natural antimicrobial peptides are cyclic, and the products of SICLOPPS are "increasingly viewed as ideal backbones for modulation of protein-protein interactions." [3] Circular peptides tend to be resistant to protease activity, and may be suitable for use as orally administered drugs.
Learn how peptides are chemically synthesized by condensation of amino acids, and how solid phase peptide synthesis (SPPS) is used to assemble peptide chains. Find out about the coupling reagents, protecting groups, and purification techniques involved in peptide synthesis.
Microcystins are cyclic heptapeptides produced by certain freshwater cyanobacteria, also known as blue-green algae. They can cause liver damage, skin irritation, and other health effects in humans and animals, and are a major problem in water quality and ecosystems.